{"entity":{"id":"slotman-pci-es-sclc","kind":"trial","name":"EORTC 08993 (Slotman): prophylactic cranial irradiation in extensive-stage small-cell lung cancer","aka":[],"tldr":"Slotman's trial showed that irradiating the brain before metastases appear cuts symptomatic brain metastases and lengthens survival in extensive-stage small-cell lung cancer, though a later Japanese trial with MRI screening did not confirm the survival gain.","summary":"EORTC 08993 randomised 286 patients with extensive-stage small-cell lung cancer who had responded to chemotherapy to prophylactic cranial irradiation or observation. Symptomatic brain metastases within a year fell from 40.4 to 14.6 percent and one-year survival rose from 13.3 to 27.1 percent (Slotman and colleagues, New England Journal of Medicine 2007). Patients were not required to have brain imaging before entry; Takahashi's 2017 trial with MRI surveillance found no survival benefit, so practice now varies.","status":"positive","asOf":"2026-09-17","links":[{"label":"NEJM 2007","url":"https://doi.org/10.1056/NEJMoa071780"}],"tags":["radiation-wave4"],"related":[],"cancers":["sclc","extensive-stage-sclc"],"sections":[],"technologies":["prophylactic-cranial-irradiation"],"targets":[],"drugs":[],"companies":["curie-nki-eortc"],"institutions":[],"pathways":[],"terms":["wbrt"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":["paper-slotman-n-engl-j-med"],"journals":[],"dependsOn":[],"notes":[],"phase":"3","setting":"Extensive-stage small-cell lung cancer responding to chemotherapy: prophylactic cranial irradiation versus observation","sponsor":"EORTC","result":"Symptomatic brain metastases at 1 year 14.6% vs 40.4%; 1-year survival 27.1% vs 13.3%.","yearReported":2007,"enrolled":286,"enrolledBasis":"registry","outcomes":[{"endpoint":"Symptomatic brain metastases within 1 year","primary":true,"unit":"%","arms":[{"name":"Prophylactic cranial irradiation","n":143,"value":14.6},{"name":"Observation","n":143,"value":40.4}]}]},"route":"/trials/slotman-pci-es-sclc/","neighbours":{"cancer":[{"id":"extensive-stage-sclc","kind":"cancer","name":"Extensive-stage small-cell lung cancer","route":"/cancers/extensive-stage-sclc/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}],"technology":[{"id":"prophylactic-cranial-irradiation","kind":"technology","name":"Prophylactic cranial irradiation vs MRI surveillance","route":"/technologies/prophylactic-cranial-irradiation/"}],"company":[{"id":"curie-nki-eortc","kind":"company","name":"EORTC","route":"/companies/curie-nki-eortc/"}],"term":[{"id":"wbrt","kind":"term","name":"Whole-brain radiotherapy (WBRT)","route":"/terms/wbrt/"}],"paper":[{"id":"paper-slotman-n-engl-j-med","kind":"paper","name":"Prophylactic cranial irradiation in extensive small-cell lung cancer","route":"/key-papers/paper-slotman-n-engl-j-med/"}],"trial":[{"id":"crest-thoracic-rt","kind":"trial","name":"CREST: consolidation thoracic radiotherapy in extensive-stage small-cell lung cancer","route":"/trials/crest-thoracic-rt/"},{"id":"pci-overview-1999","kind":"trial","name":"Prophylactic Cranial Irradiation Overview (Auperin meta-analysis)","route":"/trials/pci-overview-1999/"}]}}