{"entity":{"id":"silvana-konermann","kind":"person","name":"Silvana Konermann","aka":[],"tldr":"Neuroscientist and co-founder who runs the Arc Institute, an independent research institute in the San Francisco Bay Area built to tackle complex diseases.","summary":"Silvana Konermann is Co-Founder, Executive Director and a Core Investigator of the Arc Institute, an independent research institute she started with Patrick Hsu and Patrick Collison after the three collaborated on Fast Grants. She is also Assistant Professor of Biochemistry at Stanford, holds a PhD in neuroscience from MIT, and has been a Chan Zuckerberg Biohub Investigator and a Hanna Gray Fellow of the Howard Hughes Medical Institute. Her laboratory uses CRISPR-based transcriptome engineering and functional genomic screens in brain cell models to uncover the molecular pathways behind Alzheimer's disease and other neurodegenerative disorders.","asOf":"2026-09-10","links":[{"label":"Source: Arc Institute About page","url":"https://arcinstitute.org/about"}],"tags":["leadership","clinician-scientist","genomics","research-institute"],"related":[],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["cz-biohub","hhmi"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Executive Director and Core Investigator, Arc Institute","institutionId":"arc-institute","specialisms":["Functional genomics","CRISPR technologies","Neurodegeneration"],"profiles":[{"label":"Institution profile","url":"https://arcinstitute.org/labs/konermannlab"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Konermann+S%5BAuthor%5D"}],"papers":[{"title":"DNA targeting specificity of RNA-guided Cas9 nucleases","journal":"Nature Biotechnology","year":2013,"url":"https://doi.org/10.1038/nbt.2647","doi":"10.1038/nbt.2647","note":"Europe PMC author record matched by affiliation"},{"title":"Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity","journal":"Cell","year":2013,"url":"https://doi.org/10.1016/j.cell.2013.08.021","doi":"10.1016/j.cell.2013.08.021","note":"Europe PMC author record matched by affiliation"},{"title":"Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex","journal":"Nature","year":2015,"url":"https://doi.org/10.1038/nature14136","doi":"10.1038/nature14136","note":"Europe PMC author record matched by affiliation"}]},"route":"/people/silvana-konermann/","neighbours":{"institution":[{"id":"arc-institute","kind":"institution","name":"Arc Institute","route":"/institutions/arc-institute/"},{"id":"cz-biohub","kind":"institution","name":"Chan Zuckerberg Biohub","route":"/institutions/cz-biohub/"},{"id":"hhmi","kind":"institution","name":"Howard Hughes Medical Institute","route":"/institutions/hhmi/"}]}}