{"entity":{"id":"senthil-muthuswamy","kind":"person","name":"Senthil K. Muthuswamy","aka":[],"tldr":"Cancer biologist who directs the National Cancer Institute's Center for Cancer Research, the large intramural research programme in Bethesda.","summary":"Senthil K. Muthuswamy is Director of the Center for Cancer Research (CCR), the intramural research programme of the US National Cancer Institute, and a Senior Investigator in its Laboratory of Cancer Biology and Genetics. He pioneered three dimensional organoid culture and co-culture methods for mechanistic, translational and co-clinical studies, and his laboratory defined roles for cell polarity proteins in cancer biology and therapy resistance. His research interests include metastasis, breast and pancreatic cancer and cancer immunotherapy.","asOf":"2026-09-10","links":[{"label":"Source: CCR Office of the Director leadership page","url":"https://ccr.cancer.gov/about/office-of-the-director"}],"tags":["leadership","clinician-scientist","cancer-biology","organoids"],"related":[],"cancers":["pancreatic","breast-hr-positive"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["nci-ccr"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["breast-cancer-research"],"dependsOn":[],"notes":[],"role":"Director, Center for Cancer Research, National Cancer Institute","institutionId":"nci-ccr","specialisms":["Cancer cell biology","Organoid models","Breast and pancreatic cancer"],"profiles":[{"label":"CCR staff profile","url":"https://ccr.cancer.gov/staff-directory/senthil-k-muthuswamy"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Muthuswamy+SK%5BAuthor%5D"}],"papers":[{"title":"Establishing conditions for the generation and maintenance of estrogen receptor-positive organoid models of breast cancer","journal":"Breast Cancer Research","year":2024,"doi":"10.1186/s13058-024-01798-6"},{"title":"Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids","journal":"Nature Medicine","year":2015,"doi":"10.1038/nm.3973"},{"title":"Organoid Cultures for the Study of Mammary Biology and Breast Cancer: The Promise and Challenges","journal":"Cold Spring Harbor Perspectives in Medicine","year":2023,"doi":"10.1101/cshperspect.a041661"}]},"route":"/people/senthil-muthuswamy/","neighbours":{"cancer":[{"id":"breast-hr-positive","kind":"cancer","name":"HR-positive / HER2-negative breast cancer","route":"/cancers/breast-hr-positive/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}],"institution":[{"id":"nci","kind":"institution","name":"National Cancer Institute (NIH)","route":"/institutions/nci/"},{"id":"nci-ccr","kind":"institution","name":"NCI Center for Cancer Research (intramural programme)","route":"/institutions/nci-ccr/"}],"journal":[{"id":"breast-cancer-research","kind":"journal","name":"Breast cancer research","route":"/journals/breast-cancer-research/"}]}}