{"entity":{"id":"semir-beyaz","kind":"person","name":"Semir Beyaz","aka":[],"tldr":"Shows how diet reprogrammes intestinal stem cells and immunity to change colorectal cancer risk.","summary":"Semir Beyaz is Assistant Professor at the Cold Spring Harbor Laboratory Cancer Center, working on diet and cancer. He is known for showing how diet reprogrammes intestinal stem cells and immunity to change colorectal cancer risk, demonstrating that a high-fat diet enhances the tumorigenicity of intestinal stem cells. His selected paper reports that high-fat diet enhances stemness and tumorigenicity of intestinal progenitors. His laboratory now studies dietary and metabolic modulation of anti-tumour immunity and immunometabolism.","asOf":"2026-09-08","links":[{"label":"CSHL profile","url":"https://www.cshl.edu/research/faculty-staff/semir-beyaz/"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Beyaz%20S%5BAuthor%5D"}],"tags":[],"related":[],"cancers":["colorectal"],"sections":["prevention"],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["cold-spring-harbor"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Assistant Professor, CSHL Cancer Center","institutionId":"cold-spring-harbor","specialisms":["Diet and cancer","Intestinal stem cells","Immunometabolism"],"profiles":[{"label":"CSHL profile","url":"https://www.cshl.edu/research/faculty-staff/semir-beyaz/"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Beyaz%20S%5BAuthor%5D"}],"papers":[{"title":"High-fat diet enhances stemness and tumorigenicity of intestinal progenitors","journal":"Nature","year":2016,"url":"https://doi.org/10.1038/nature17173","doi":"10.1038/nature17173"}],"orcid":"0000-0003-4730-4012"},"route":"/people/semir-beyaz/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}],"section":[{"id":"prevention","kind":"section","name":"Prevention & Risk","route":"/fronts/prevention/"}],"institution":[{"id":"cold-spring-harbor","kind":"institution","name":"Cold Spring Harbor Laboratory","route":"/institutions/cold-spring-harbor/"}]}}