{"entity":{"id":"science-translational-medicine","kind":"journal","name":"Science Translational Medicine","aka":["Sci Transl Med"],"tldr":"Science Translational Medicine is AAAS's translational journal, publishing the bench-to-bedside cancer papers on liquid biopsy, CAR-T engineering, tumour-immune biology and new imaging agents.","summary":"Science Translational Medicine (Sci Transl Med) is the translational journal of the American Association for the Advancement of Science (AAAS), founded in 2009, appearing weekly and available by subscription with delayed free access. It publishes bench-to-bedside studies with strong mechanistic grounding, including early circulating tumour DNA detection methods, CAR-T design and toxicity work, tumour-immune biology and PET tracer development. Its readers are translational researchers moving discoveries toward the clinic. Within OnCo it is linked from the biographies of Lecia Sequist, Jeanne Tie, Michel Sadelain, Marcela Maus, Marie-Catherine Vozenin and Constance Lehman, and a reader would use it for the liquid biopsy, CAR-T and imaging papers that precede trials.","asOf":"2026-09-09","links":[{"label":"Science journals","url":"https://www.science.org"}],"tags":[],"related":[],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"publisher":"American Association for the Advancement of Science","url":"https://www.science.org/journal/stm","issn":"1946-6234","scope":"translational medicine","founded":2009,"matchNames":["Science Translational Medicine","Sci Transl Med"],"society":"American Association for the Advancement of Science"},"route":"/journals/science-translational-medicine/","neighbours":{"paper":[{"id":"paper-bourgeois-daigneault-neoadjuvant-ovt-tnbc-scitranslmed-2018","kind":"paper","name":"Bourgeois-Daigneault 2018: giving the virus before surgery, not after everything else has failed","route":"/key-papers/paper-bourgeois-daigneault-neoadjuvant-ovt-tnbc-scitranslmed-2018/"},{"id":"paper-tie-ctdna-minimal-residual-disease-stage-ii-colon-sci-transl-med-2016","kind":"paper","name":"Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer","route":"/key-papers/paper-tie-ctdna-minimal-residual-disease-stage-ii-colon-sci-transl-med-2016/"},{"id":"paper-scherer-ctdna-lymphoma-subtypes-genome-evolution-sci-transl-med-2016","kind":"paper","name":"Distinct biological subtypes and patterns of genome evolution in lymphoma revealed by circulating tumour DNA","route":"/key-papers/paper-scherer-ctdna-lymphoma-subtypes-genome-evolution-sci-transl-med-2016/"},{"id":"paper-weiss-fgfr1-amplification-squamous-lung-sci-transl-med-2010","kind":"paper","name":"Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer","route":"/key-papers/paper-weiss-fgfr1-amplification-squamous-lung-sci-transl-med-2010/"},{"id":"paper-sequist-genotypic-histological-evolution-egfr-resistance-sci-transl-med-2011","kind":"paper","name":"Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors","route":"/key-papers/paper-sequist-genotypic-histological-evolution-egfr-resistance-sci-transl-med-2011/"},{"id":"paper-garcia-murillas-ctdna-mutation-tracking-stm-2015","kind":"paper","name":"Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer","route":"/key-papers/paper-garcia-murillas-ctdna-mutation-tracking-stm-2015/"},{"id":"paper-wu-gnas-ipmn-sci-transl-med-2011","kind":"paper","name":"Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development","route":"/key-papers/paper-wu-gnas-ipmn-sci-transl-med-2011/"},{"id":"paper-yala-sci-transl-med","kind":"paper","name":"Toward robust mammography-based models for breast cancer risk","route":"/key-papers/paper-yala-sci-transl-med/"}],"person":[{"id":"constance-lehman","kind":"person","name":"Constance D. Lehman","route":"/people/constance-lehman/"},{"id":"jeanne-tie","kind":"person","name":"Jeanne Tie","route":"/people/jeanne-tie/"},{"id":"lecia-sequist","kind":"person","name":"Lecia V. Sequist","route":"/people/lecia-sequist/"},{"id":"marcela-maus","kind":"person","name":"Marcela V. Maus","route":"/people/marcela-maus/"},{"id":"marie-catherine-vozenin","kind":"person","name":"Marie-Catherine Vozenin","route":"/people/marie-catherine-vozenin/"},{"id":"michel-sadelain","kind":"person","name":"Michel Sadelain","route":"/people/michel-sadelain/"},{"id":"ulrich-steidl","kind":"person","name":"Ulrich G. Steidl","route":"/people/ulrich-steidl/"}]}}