{"entity":{"id":"sarcoma-type","kind":"term","name":"Sarcoma (tissue type)","aka":["sarcomas","soft-tissue sarcoma","soft tissue sarcoma","bone sarcoma","connective tissue cancer","mesenchymal","bone sarcomas","soft-tissue sarcomas"],"tldr":"Cancer of the body's connective and supporting tissues: bone, muscle, fat, cartilage, blood vessels, fibrous tissue. Rare (about 1% of adult cancers) but relatively common in children.","summary":"Sarcomas come from mesenchymal cells rather than the epithelial lining cells that give rise to carcinomas, and there are more than seventy subtypes, often defined by a specific gene fusion (EWSR1-FLI1 in Ewing sarcoma, SS18-SSX in synovial sarcoma) or by a single driver (KIT in GIST). They are treated in specialist centres by surgery and radiotherapy, with chemotherapy for the more aggressive types; GIST was one of the first solid tumours transformed by a targeted drug (imatinib), and fusion-defined sarcomas are natural candidates for precision approaches. Because they are rare and diverse, sarcomas depend heavily on referral networks, registries and international trials.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Sarcoma","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Sarcoma"}],"tags":[],"related":["carcinoma","gene-fusion","rare-cancers","lymphoma-type"],"cancers":["sarcoma"],"sections":[],"technologies":[],"targets":["kit"],"drugs":["imatinib"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Biology basics"},"route":"/terms/sarcoma-type/","neighbours":{"term":[{"id":"carcinoma","kind":"term","name":"Carcinoma","route":"/terms/carcinoma/"},{"id":"gene-fusion","kind":"term","name":"Gene fusion","route":"/terms/gene-fusion/"},{"id":"lymphoma-type","kind":"term","name":"Lymphoma (tissue type)","route":"/terms/lymphoma-type/"},{"id":"rare-cancers","kind":"term","name":"Rare cancers","route":"/terms/rare-cancers/"}],"cancer":[{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}],"target":[{"id":"kit","kind":"target","name":"KIT","route":"/targets/kit/"}],"drug":[{"id":"imatinib","kind":"drug","name":"Imatinib","route":"/drugs/imatinib/"}]}}