{"entity":{"id":"salvage-therapy","kind":"term","name":"Salvage therapy","aka":["salvage","salvage chemotherapy","salvage surgery","salvage radiotherapy","salvage treatment","salvage regimen","salvage cystectomy","salvage laryngectomy","salvage transplant"],"tldr":"Treatment given after the first treatment has failed or the cancer has come back, aiming to rescue the situation. It can still be curative (salvage surgery after organ-preservation fails) or a later line of palliation.","summary":"Salvage surgery removes the organ when chemoradiation or watch-and-wait fails (laryngectomy, cystectomy, abdominoperineal resection, TME after regrowth). Salvage radiotherapy treats a rising PSA after prostatectomy; salvage chemotherapy (ICE, DHAP, GDP) followed by autologous transplant was the standard for relapsed lymphoma until CAR-T proved superior in second line (ZUMA-7, TRANSFORM). Organ-preservation strategies are only safe where salvage is feasible and centres have the surgical capacity to deliver it.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Salvage_therapy","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Salvage_therapy"}],"tags":[],"related":["organ-preservation","relapsed-refractory","first-line","autologous-transplant"],"cancers":[],"sections":["surgery","chemotherapy"],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["zuma-7","transform"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Treatment jargon"},"route":"/terms/salvage-therapy/","neighbours":{"term":[{"id":"autologous-transplant","kind":"term","name":"Autologous stem cell transplant (ASCT)","route":"/terms/autologous-transplant/"},{"id":"bridging-therapy","kind":"term","name":"Bridging therapy","route":"/terms/bridging-therapy/"},{"id":"first-line","kind":"term","name":"Lines of therapy","route":"/terms/first-line/"},{"id":"organ-preservation","kind":"term","name":"Organ preservation (watch-and-wait, bladder-sparing, larynx preservation)","route":"/terms/organ-preservation/"},{"id":"r-chop","kind":"term","name":"R-CHOP (lymphoma chemoimmunotherapy)","route":"/terms/r-chop/"},{"id":"re-irradiation","kind":"term","name":"Re-irradiation","route":"/terms/re-irradiation/"},{"id":"relapsed-refractory","kind":"term","name":"Relapsed / refractory (R/R)","route":"/terms/relapsed-refractory/"},{"id":"lymphoma-tx-transplant-role","kind":"term","name":"Stem cell transplant in lymphoma: what it is still for","route":"/terms/lymphoma-tx-transplant-role/"}],"section":[{"id":"chemotherapy","kind":"section","name":"Chemotherapy","route":"/fronts/chemotherapy/"},{"id":"surgery","kind":"section","name":"Surgery & Interventional","route":"/fronts/surgery/"}],"trial":[{"id":"artistic-meta-analysis","kind":"trial","name":"ARTISTIC meta-analysis","route":"/trials/artistic-meta-analysis/"},{"id":"getug-afu-16","kind":"trial","name":"GETUG-AFU 16","route":"/trials/getug-afu-16/"},{"id":"getug-afu-17","kind":"trial","name":"GETUG-AFU 17","route":"/trials/getug-afu-17/"},{"id":"radicals-hd","kind":"trial","name":"RADICALS-HD","route":"/trials/radicals-hd/"},{"id":"radicals-rt","kind":"trial","name":"RADICALS-RT","route":"/trials/radicals-rt/"},{"id":"raves","kind":"trial","name":"RAVES (TROG 08.03/ANZUP)","route":"/trials/raves/"},{"id":"swog-8794","kind":"trial","name":"SWOG 8794","route":"/trials/swog-8794/"},{"id":"transform","kind":"trial","name":"TRANSFORM","route":"/trials/transform/"},{"id":"zuma-7","kind":"trial","name":"ZUMA-7","route":"/trials/zuma-7/"}]}}