{"entity":{"id":"salk-institute","kind":"institution","name":"Salk Institute Cancer Center","aka":["Salk Institute for Biological Studies"],"tldr":"Jonas Salk's institute, an NCI basic cancer centre since 1973, where tyrosine phosphorylation and much of nuclear receptor and metabolism biology were discovered.","summary":"The Salk Institute's cancer centre has held NCI basic laboratory designation since 1973. Tony Hunter discovered tyrosine phosphorylation here in 1979, the biochemical foundation of every kinase inhibitor; Inder Verma pioneered retroviral and lentiviral gene delivery; Ronald Evans's nuclear receptor work led to vitamin D receptor-targeted stromal reprogramming in pancreatic cancer; Reuben Shaw dissected the LKB1-AMPK metabolic checkpoint. Geoffrey Wahl's breast cancer stem cell biology and Susan Kaech's T-cell exhaustion research connect the institute to immunotherapy. Salk has no clinic and works through collaborations with UC San Diego and other La Jolla institutions.","asOf":"2026-09-09","links":[{"label":"Salk Cancer Center","url":"https://www.salk.edu/science/research-centers/salk-cancer-center/"},{"label":"Salk Institute","url":"https://www.salk.edu"}],"tags":[],"related":[],"cancers":["pancreatic","tnbc"],"sections":["drug-discovery","targeted-therapy"],"technologies":["kinase-inhibitors","metabolic-therapy"],"targets":[],"drugs":[],"companies":[],"institutions":["ucsd-moores"],"pathways":[],"terms":[],"trials":[],"people":["reuben-shaw"],"bottlenecks":["b-tme-immunosuppression"],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"La Jolla, CA","country":"US","lat":32.887,"lng":-117.246,"institutionType":"research-institute","website":"https://www.salk.edu/science/research-centers/salk-cancer-center/","nci":"basic","programs":["Kinase signalling","Nuclear receptors and the tumour stroma","Cancer metabolism","T-cell biology"]},"route":"/institutions/salk-institute/","neighbours":{"cancer":[{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"tnbc","kind":"cancer","name":"Triple-negative breast cancer (TNBC)","route":"/cancers/tnbc/"}],"section":[{"id":"drug-discovery","kind":"section","name":"Drug Discovery Platforms","route":"/fronts/drug-discovery/"},{"id":"targeted-therapy","kind":"section","name":"Targeted Therapy","route":"/fronts/targeted-therapy/"}],"technology":[{"id":"metabolic-therapy","kind":"technology","name":"Metabolic therapy: starving the tumour of a nutrient","route":"/technologies/metabolic-therapy/"},{"id":"kinase-inhibitors","kind":"technology","name":"Small-molecule kinase inhibitors","route":"/technologies/kinase-inhibitors/"}],"institution":[{"id":"nci","kind":"institution","name":"National Cancer Institute (NIH)","route":"/institutions/nci/"},{"id":"ucsd-moores","kind":"institution","name":"UC San Diego Moores Cancer Center","route":"/institutions/ucsd-moores/"}],"person":[{"id":"reuben-shaw","kind":"person","name":"Reuben Shaw","route":"/people/reuben-shaw/"}],"bottleneck":[{"id":"b-tme-immunosuppression","kind":"bottleneck","name":"Cold tumours and the immunosuppressive microenvironment","route":"/bottlenecks/b-tme-immunosuppression/"}],"collection":[{"id":"nci-cancer-centers","kind":"collection","name":"NCI-Designated Cancer Centers","route":"/collections/nci-cancer-centers/"}]}}