{"entity":{"id":"sagar-lonial","kind":"person","name":"Sagar Lonial","aka":[],"tldr":"Led SIRIUS and the DREAMM programme, bringing daratumumab monotherapy and the BCMA ADC belantamab to myeloma.","summary":"Sagar Lonial led SIRIUS, the trial that won daratumumab its first approval as monotherapy in relapsed myeloma, and DREAMM-2, the pivotal trial of belantamab mafodotin, the first BCMA-directed ADC. He has led the Emory series showing near-universal deep responses to RVd induction and chairs the myeloma committee of the SWOG cooperative group.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Lonial%20S%5BAuthor%5D%20myeloma%20belantamab%20OR%20daratumumab"}],"tags":["myeloma","adc","swog"],"related":[],"cancers":["multiple-myeloma"],"sections":[],"technologies":["adc","monoclonal-antibody"],"targets":["bcma","cd38"],"drugs":["belantamab-mafodotin"],"companies":[],"institutions":["emory-winship"],"pathways":[],"terms":[],"trials":["dreamm-7","dreamm-8"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Chair of Hematology and Medical Oncology and Chief Medical Officer, Winship Cancer Institute of Emory University","institutionId":"emory-winship","specialisms":["Multiple myeloma","Antibody-drug conjugates","Daratumumab","High-risk myeloma"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Lonial%20S%5BAuthor%5D%20myeloma%20belantamab%20OR%20daratumumab"}],"papers":[{"title":"Daratumumab monotherapy in patients with treatment-refractory multiple myeloma (SIRIUS)","journal":"Lancet","year":2016,"doi":"10.1016/S0140-6736(15)01120-4"},{"title":"Belantamab mafodotin for relapsed or refractory multiple myeloma (DREAMM-2)","journal":"Lancet Oncology","year":2020,"doi":"10.1016/S1470-2045(19)30788-0"}]},"route":"/people/sagar-lonial/","neighbours":{"cancer":[{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"}],"technology":[{"id":"adc","kind":"technology","name":"Antibody-drug conjugate (ADC)","route":"/technologies/adc/"},{"id":"monoclonal-antibody","kind":"technology","name":"Monoclonal antibodies","route":"/technologies/monoclonal-antibody/"}],"target":[{"id":"bcma","kind":"target","name":"BCMA","route":"/targets/bcma/"},{"id":"cd38","kind":"target","name":"CD38","route":"/targets/cd38/"}],"drug":[{"id":"belantamab-mafodotin","kind":"drug","name":"Belantamab mafodotin","route":"/drugs/belantamab-mafodotin/"}],"institution":[{"id":"emory-winship","kind":"institution","name":"Winship Cancer Institute of Emory University","route":"/institutions/emory-winship/"}],"trial":[{"id":"dreamm-7","kind":"trial","name":"DREAMM-7","route":"/trials/dreamm-7/"},{"id":"dreamm-8","kind":"trial","name":"DREAMM-8","route":"/trials/dreamm-8/"}]}}