{"entity":{"id":"s1pr2","kind":"target","name":"S1PR2","aka":["sphingosine-1-phosphate receptor 2","Sphingosine 1-phosphate receptor 2","Gpcr13","H218","AGR16","EDG5","DFNB68"],"tldr":"S1PR2 (Sphingosine 1-phosphate receptor 2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.","summary":"Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3169","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3169"},{"label":"UniProt O95136","url":"https://www.uniprot.org/uniprotkb/O95136/entry"},{"label":"NCBI Gene 9294","url":"https://www.ncbi.nlm.nih.gov/gene/9294"},{"label":"Ensembl ENSG00000267534","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000267534"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["dlbcl"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"S1PR2","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:3169","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3169","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O95136","url":"https://www.uniprot.org/uniprotkb/O95136/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene S1PR2","url":"https://civicdb.org/features/7339","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA S1PR2: RNA low tissue specificity; blood lineage group enriched (granulocytes 45 nTPM, T-cells 12 nTPM); high antibody staining in 2 normal tissues; highest cancer staining renal cancer (1 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas S1PR2 tissue","url":"https://www.proteinatlas.org/ENSG00000267534-S1PR2/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000267534 associations","url":"https://platform.opentargets.org/target/ENSG00000267534/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:3169","ensembl":"ENSG00000267534","uniprot":"O95136","entrez":"9294","firstDescribed":2000,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: An et al, J. Biol. Chem, 2000, \"Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10617617/","biology":"Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. Receptor for the chemokine-like protein FAM19A5. Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration. In lymphoid follicles, couples the binding of S1P to the activation of GNA13 and downstream inhibition of AKT activation leading to suppression of germinal centre (GC) B cell growth and migration outside the GC niche. Location: Cell membrane (UniProt). Locus 19p13.2 (HGNC).","whereFound":["Diffuse large B-cell lymphoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/s1pr2/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"}]}}