{"entity":{"id":"ruth-ladenstein","kind":"person","name":"Ruth Ladenstein","aka":[],"tldr":"Chaired the SIOPEN HR-NBL1 trial, the largest neuroblastoma trial ever, which set European standards for high-risk disease.","summary":"Ruth Ladenstein (Vienna) chaired SIOPEN HR-NBL1, the 3,000-patient trial that established busulfan-melphalan as the preferred myeloablative regimen for high-risk neuroblastoma and showed that adding interleukin-2 to dinutuximab beta immunotherapy adds toxicity without benefit. She has led SIOP Europe and coordinates the European neuroblastoma research network.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Ladenstein%20R%5BAuthor%5D%20neuroblastoma"}],"tags":["paediatric","neuroblastoma","cooperative-group"],"related":[],"cancers":["neuroblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["st-anna-ccri-vienna"],"pathways":[],"terms":[],"trials":["hr-nbl1"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Professor of Paediatrics, St. Anna Children's Hospital and Children's Cancer Research Institute, Vienna","institutionId":"st-anna-ccri-vienna","specialisms":["Neuroblastoma","High-dose chemotherapy","European paediatric trials","Immunotherapy"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Ladenstein%20R%5BAuthor%5D%20neuroblastoma"}],"papers":[{"title":"Busulfan and melphalan versus carboplatin, etoposide, and melphalan as high-dose chemotherapy for high-risk neuroblastoma (HR-NBL1/SIOPEN)","journal":"Lancet Oncology","year":2017,"doi":"10.1016/S1470-2045(17)30070-0"},{"title":"Interleukin 2 with anti-GD2 antibody ch14.18/CHO (dinutuximab beta) in patients with high-risk neuroblastoma (HR-NBL1/SIOPEN)","journal":"Lancet Oncology","year":2018,"doi":"10.1016/S1470-2045(18)30578-3"}],"orcid":"0000-0001-6548-3873"},"route":"/people/ruth-ladenstein/","neighbours":{"cancer":[{"id":"neuroblastoma","kind":"cancer","name":"Neuroblastoma (paediatric)","route":"/cancers/neuroblastoma/"}],"institution":[{"id":"st-anna-ccri-vienna","kind":"institution","name":"St. Anna Children's Hospital and Children's Cancer Research Institute (CCRI)","route":"/institutions/st-anna-ccri-vienna/"}],"trial":[{"id":"hr-nbl1","kind":"trial","name":"SIOPEN HR-NBL1","route":"/trials/hr-nbl1/"}]}}