{"entity":{"id":"ruijin-hospital","kind":"institution","name":"Ruijin Hospital, Shanghai Jiao Tong University","aka":["Ruijin Hospital","瑞金医院","Shanghai Institute of Hematology"],"tldr":"The hospital where all-trans retinoic acid and arsenic cured acute promyelocytic leukaemia, and still China's leading haematology centre.","summary":"Ruijin Hospital dates to 1907 and is home to the Shanghai Institute of Hematology, where Zhen-Yi Wang and Zhu Chen established differentiation therapy of acute promyelocytic leukaemia with all-trans retinoic acid and then arsenic trioxide, turning a lethal leukaemia into one of the most curable. The institute remains a global reference for APL, AML genomics and lymphoma, and hosts national CAR-T and haematopoietic transplant programmes. Ruijin is also a major centre for gastric cancer surgery, pancreatic surgery, endocrine tumours and burns, and runs one of Shanghai's proton therapy projects.","asOf":"2026-09-09","links":[{"label":"Ruijin Hospital","url":"https://www.rjh.com.cn"},{"label":"Shanghai Jiao Tong University School of Medicine","url":"https://www.shsmu.edu.cn"},{"label":"PTCOG: particle therapy facilities in operation","url":"https://www.ptcog.site/index.php/facilities-in-operation-public"}],"tags":[],"related":[],"cancers":["aml","dlbcl","all-leukemia","gastric","pancreatic"],"sections":["chemotherapy","cell-therapy","epigenetics"],"technologies":["car-t","proton-therapy","epigenetic-drugs","proton-therapy-systems"],"targets":[],"drugs":["arsenic-trioxide","tretinoin-atra"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":["chen-saijuan","chen-zhu"],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"Shanghai","country":"CN","lat":31.213,"lng":121.467,"institutionType":"hospital","website":"https://www.rjh.com.cn","university":"Shanghai Jiao Tong University","programs":["Shanghai Institute of Hematology","APL differentiation therapy","Lymphoma","Gastric and pancreatic surgery","Proton therapy"]},"route":"/institutions/ruijin-hospital/","neighbours":{"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}],"section":[{"id":"cell-therapy","kind":"section","name":"Cell Therapy","route":"/fronts/cell-therapy/"},{"id":"chemotherapy","kind":"section","name":"Chemotherapy","route":"/fronts/chemotherapy/"},{"id":"epigenetics","kind":"section","name":"Epigenetic & Transcriptional Therapy","route":"/fronts/epigenetics/"}],"technology":[{"id":"car-t","kind":"technology","name":"CAR-T cell therapy","route":"/technologies/car-t/"},{"id":"epigenetic-drugs","kind":"technology","name":"Epigenetic drugs (HDAC, DNMT, EZH2, IDH, menin, BET)","route":"/technologies/epigenetic-drugs/"},{"id":"proton-therapy","kind":"technology","name":"Proton therapy","route":"/technologies/proton-therapy/"},{"id":"proton-therapy-systems","kind":"technology","name":"Proton therapy machines: cyclotrons, synchrotrons and single-room systems","route":"/technologies/proton-therapy-systems/"}],"drug":[{"id":"arsenic-trioxide","kind":"drug","name":"Arsenic trioxide","route":"/drugs/arsenic-trioxide/"},{"id":"tretinoin-atra","kind":"drug","name":"Tretinoin (all-trans retinoic acid, ATRA)","route":"/drugs/tretinoin-atra/"}],"person":[{"id":"chen-saijuan","kind":"person","name":"Saijuan Chen","route":"/people/chen-saijuan/"},{"id":"chen-zhu","kind":"person","name":"Zhu Chen","route":"/people/chen-zhu/"}]}}