{"entity":{"id":"ross-levine","kind":"person","name":"Ross L. Levine","aka":[],"tldr":"Discovered the JAK2 mutation behind most myeloproliferative neoplasms and defined the genetics of clonal haematopoiesis.","summary":"Ross L. Levine is Chair of the Center for Hematologic Malignancies and a Member of the Human Oncology and Pathogenesis Program at Memorial Sloan Kettering Cancer Center. He is a physician-scientist known for discovering the JAK2 V617F mutation behind most myeloproliferative neoplasms and for defining the genetics of clonal haematopoiesis through TET2, ASXL1 and other mutations. His selected paper reports the activating JAK2 mutation in polycythaemia vera, essential thrombocythaemia and myeloid metaplasia with myelofibrosis. His laboratory continues to study how these mutations drive leukaemia evolution.","asOf":"2026-09-08","links":[{"label":"MSK lab","url":"https://www.mskcc.org/research-areas/labs/ross-levine"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Levine%20RL%5BAuthor%5D"}],"tags":[],"related":[],"cancers":["aml"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["mskcc"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["cancer-cell"],"dependsOn":[],"notes":[],"role":"Chair, Center for Hematologic Malignancies; Member, Human Oncology and Pathogenesis Program","institutionId":"mskcc","specialisms":["Myeloid malignancies","Clonal haematopoiesis","JAK2 and epigenetic regulators"],"profiles":[{"label":"MSK lab","url":"https://www.mskcc.org/research-areas/labs/ross-levine"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Levine%20RL%5BAuthor%5D"}],"papers":[{"title":"Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis","journal":"Cancer Cell","year":2005,"url":"https://doi.org/10.1016/j.ccr.2005.03.023","doi":"10.1016/j.ccr.2005.03.023"}],"orcid":"0000-0002-7884-1905"},"route":"/people/ross-levine/","neighbours":{"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"}],"institution":[{"id":"ash","kind":"institution","name":"American Society of Hematology","route":"/institutions/ash/"},{"id":"mskcc","kind":"institution","name":"Memorial Sloan Kettering Cancer Center","route":"/institutions/mskcc/"}],"journal":[{"id":"cancer-cell","kind":"journal","name":"Cancer Cell","route":"/journals/cancer-cell/"}],"trial":[{"id":"beat-aml-master-trial","kind":"trial","name":"Beat AML Master Trial","route":"/trials/beat-aml-master-trial/"}]}}