{"entity":{"id":"ron","kind":"target","name":"RON receptor (MST1R)","aka":[],"tldr":"RON is a receptor kinase from the same family as MET; multi-kinase drugs such as crizotinib and cabozantinib hit it as well as their main targets.","summary":"Macrophage-stimulating protein receptor (RON, gene MST1R) is the sister receptor of MET, activated by MSP and overexpressed or aberrantly spliced in several carcinomas, where it promotes invasion and macrophage-driven inflammation. It is not a primary approval target, but crizotinib, cabozantinib and other MET-family inhibitors inhibit it and ChEMBL lists it among their targets.","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/MST1R","links":[{"label":"UniProt Q04912: MST1R","url":"https://www.uniprot.org/uniprotkb/Q04912/entry"},{"label":"HGNC:7381 MST1R","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7381"},{"label":"ChEMBL target CHEMBL2689","url":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL2689"}],"tags":[],"related":["met"],"cancers":["nsclc","colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":["crizotinib","cabozantinib"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"symbol":"MST1R","role":[],"sources":[],"specificity":"tumour-associated","distribution":"few-types","specificityNote":"Tumour-associated overexpression: HPA finds the RNA tissue enhanced in normal intestine, skin 1, stomach 1, so the tumour and the normal tissue it comes from share the target and the medicine relies on the difference in level. HPA MST1R: RNA tissue enhanced (intestine 18 nTPM, skin 1 30 nTPM, stomach 1 26 nTPM); high antibody staining in 5 normal tissues; highest cancer staining melanoma (10 of 12 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Lung cancer (all types), Colorectal cancer); Open Targets associates it with 1 specific cancer type at or above 0.5 (non-small cell lung carcinoma). (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas MST1R tissue","url":"https://www.proteinatlas.org/ENSG00000164078-MST1R/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Human Protein Atlas MST1R pathology","url":"https://www.proteinatlas.org/ENSG00000164078-MST1R/pathology","note":"patients per staining level per cancer type (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000164078 associations","url":"https://platform.opentargets.org/target/ENSG00000164078/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:7381","ensembl":"ENSG00000164078","uniprot":"Q04912","entrez":"4486","firstDescribed":1993,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Ronsin et al, Oncogene, 1993, \"A novel putative receptor protein tyrosine kinase of the met family\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/8386824/","biology":"A receptor tyrosine kinase signalling through PI3K, MAPK and beta-catenin pathways; short isoforms act as constitutively active oncogenes.","whereFound":["Overexpressed in subsets of breast, colon, pancreatic and lung carcinomas","Macrophages"],"targetClass":"kinase","prevalence":[{"cancerId":"metastatic-cancer","pct":"all","measure":"Signalling protein present in most cells (RON receptor kinase, a secondary target of MET drugs); drugs act on the pathway rather than on a mutation that selects patients, so no prevalence applies."}]},"route":"/targets/ron/","neighbours":{"target":[{"id":"met","kind":"target","name":"MET","route":"/targets/met/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"drug":[{"id":"cabozantinib","kind":"drug","name":"Cabozantinib","route":"/drugs/cabozantinib/"},{"id":"crizotinib","kind":"drug","name":"Crizotinib","route":"/drugs/crizotinib/"}]}}