{"entity":{"id":"roman-thomas","kind":"person","name":"Roman Thomas","aka":[],"tldr":"Roman Thomas is a cancer genomicist who mapped the genomes of small-cell lung cancer.","summary":"Roman Thomas is Director of the Department of Translational Genomics at the University of Cologne (CIO). A cancer genomicist, his specialisms are cancer genomics, small-cell lung cancer and lung cancer biology, with a focus on TP53. He led the comprehensive genomic profiling of small-cell lung cancer, reported in Nature, which showed near-universal loss of TP53 and RB1 in the disease. He has also characterised squamous lung cancer and the neuroendocrine transformation of non-small-cell lung cancer. His publications are listed on PubMed.","asOf":"2026-09-08","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Thomas%20RK%5BAuthor%5D%20small%20cell%20lung%20cancer%20genomic"}],"tags":[],"related":[],"cancers":["sclc","nsclc"],"sections":[],"technologies":[],"targets":["tp53"],"drugs":[],"companies":[],"institutions":["uniklinik-koeln"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Director, Department of Translational Genomics, University of Cologne","institutionId":"uniklinik-koeln","specialisms":["Cancer genomics","Small-cell lung cancer","Lung cancer biology"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Thomas%20RK%5BAuthor%5D%20small%20cell%20lung%20cancer%20genomic"}],"papers":[{"title":"Comprehensive genomic profiles of small cell lung cancer","journal":"Nature","year":2015,"doi":"10.1038/nature14664"}]},"route":"/people/roman-thomas/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}],"target":[{"id":"tp53","kind":"target","name":"TP53","route":"/targets/tp53/"}],"institution":[{"id":"uniklinik-koeln","kind":"institution","name":"Uniklinik Köln (CIO)","route":"/institutions/uniklinik-koeln/"}],"paper":[{"id":"paper-fernandez-cuesta-cd74-nrg1-fusion-lung-cancer-discov-2014","kind":"paper","name":"CD74-NRG1 fusions in lung adenocarcinoma","route":"/key-papers/paper-fernandez-cuesta-cd74-nrg1-fusion-lung-cancer-discov-2014/"},{"id":"paper-george-sclc-genomic-profiles-nature-2015","kind":"paper","name":"Comprehensive genomic profiles of small cell lung cancer","route":"/key-papers/paper-george-sclc-genomic-profiles-nature-2015/"},{"id":"paper-weiss-fgfr1-amplification-squamous-lung-sci-transl-med-2010","kind":"paper","name":"Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer","route":"/key-papers/paper-weiss-fgfr1-amplification-squamous-lung-sci-transl-med-2010/"}]}}