{"entity":{"id":"roger-stupp","kind":"person","name":"Roger Stupp","aka":[],"tldr":"Led the EORTC/NCIC trial that made temozolomide with radiotherapy the glioblastoma standard, and the EF-14 trial of tumour treating fields.","summary":"Roger Stupp is Professor of Neurological Surgery and Neurology at Northwestern University in Chicago, having previously worked in Lausanne and with the EORTC. His specialisms are neuro-oncology, glioblastoma and tumour treating fields. He led the EORTC 26981/NCIC CE.3 trial, reported in the New England Journal of Medicine as radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma, which defined the Stupp protocol that remains the glioblastoma standard. He also led EF-14, the JAMA trial that added tumour treating fields to maintenance temozolomide, the basis for the Optune device. His publications are listed on PubMed.","asOf":"2026-09-08","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Stupp%20R%5BAuthor%5D%20glioblastoma%20temozolomide"}],"tags":[],"related":[],"cancers":["glioblastoma"],"sections":[],"technologies":["ttfields"],"targets":[],"drugs":["temozolomide","optune"],"companies":["curie-nki-eortc"],"institutions":[],"pathways":[],"terms":[],"trials":["eortc-26981","ef-14"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Professor of Neurological Surgery and Neurology, Northwestern University; formerly Lausanne and EORTC","institutionId":"curie-nki-eortc","specialisms":["Neuro-oncology","Glioblastoma","Tumour treating fields"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Stupp%20R%5BAuthor%5D%20glioblastoma%20temozolomide"}],"papers":[{"title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","journal":"NEJM","year":2005,"doi":"10.1056/NEJMoa043330"},{"title":"Effect of tumor-treating fields plus maintenance temozolomide vs maintenance temozolomide alone on survival in patients with glioblastoma (EF-14)","journal":"JAMA","year":2017,"doi":"10.1001/jama.2017.18718"}]},"route":"/people/roger-stupp/","neighbours":{"cancer":[{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"}],"technology":[{"id":"ttfields","kind":"technology","name":"Tumour treating fields (TTFields)","route":"/technologies/ttfields/"}],"drug":[{"id":"optune","kind":"drug","name":"Optune / Optune Pax (TTFields)","route":"/drugs/optune/"},{"id":"temozolomide","kind":"drug","name":"Temozolomide","route":"/drugs/temozolomide/"}],"company":[{"id":"curie-nki-eortc","kind":"company","name":"EORTC","route":"/companies/curie-nki-eortc/"}],"trial":[{"id":"ef-14","kind":"trial","name":"EF-14","route":"/trials/ef-14/"},{"id":"eortc-26981","kind":"trial","name":"EORTC 26981 / NCIC CE.3 (Stupp trial)","route":"/trials/eortc-26981/"}],"idea":[{"id":"idea-bio2-robotic-convection-delivery","kind":"idea","name":"Robot-placed catheters and live imaging for drug infusion into brain tumours","route":"/ideas/idea-bio2-robotic-convection-delivery/"}],"paper":[{"id":"paper-stupp-temozolomide-nejm-2005","kind":"paper","name":"Stupp 2005: temozolomide added to radiotherapy for newly diagnosed glioblastoma","route":"/key-papers/paper-stupp-temozolomide-nejm-2005/"}],"institution":[{"id":"chuv-lausanne","kind":"institution","name":"Lausanne University Hospital (CHUV) / Ludwig Institute Lausanne","route":"/institutions/chuv-lausanne/"},{"id":"northwestern-lurie","kind":"institution","name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","route":"/institutions/northwestern-lurie/"}]}}