{"entity":{"id":"robert-gatenby","kind":"person","name":"Robert A. Gatenby","aka":[],"tldr":"Applies evolutionary game theory to cancer treatment, dosing drugs to control rather than eradicate resistant clones.","summary":"Robert A. Gatenby is Chair of the Department of Radiology and Co-Director of the Center of Excellence for Evolutionary Therapy at Moffitt Cancer Center. He is a radiologist and mathematical oncologist known for applying evolutionary game theory to cancer treatment, dosing drugs to control rather than eradicate resistant clones. He founded Moffitt's Integrated Mathematical Oncology department and ran the first adaptive-therapy trial, using abiraterone in prostate cancer. His selected paper describes integrating evolutionary dynamics into the treatment of metastatic castration-resistant prostate cancer.","asOf":"2026-09-08","links":[{"label":"Moffitt profile","url":"https://www.moffitt.org/research-science/researchers/robert-gatenby/"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Gatenby%20RA%5BAuthor%5D"}],"tags":[],"related":[],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":["abiraterone"],"companies":[],"institutions":["moffitt"],"pathways":[],"terms":["resistance"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["nature-communications"],"dependsOn":[],"notes":[],"role":"Chair, Department of Radiology; Co-Director, Center of Excellence for Evolutionary Therapy","institutionId":"moffitt","specialisms":["Evolutionary therapy","Mathematical oncology","Adaptive dosing"],"profiles":[{"label":"Moffitt profile","url":"https://www.moffitt.org/research-science/researchers/robert-gatenby/"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Gatenby%20RA%5BAuthor%5D"}],"papers":[{"title":"Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer","journal":"Nature Communications","year":2017,"url":"https://doi.org/10.1038/s41467-017-01968-5","doi":"10.1038/s41467-017-01968-5"}]},"route":"/people/robert-gatenby/","neighbours":{"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"drug":[{"id":"abiraterone","kind":"drug","name":"Abiraterone acetate","route":"/drugs/abiraterone/"}],"institution":[{"id":"moffitt","kind":"institution","name":"Moffitt Cancer Center","route":"/institutions/moffitt/"}],"term":[{"id":"clonal-evolution-theory","kind":"term","name":"Clonal evolution and the ecological view of cancer","route":"/terms/clonal-evolution-theory/"},{"id":"resistance","kind":"term","name":"Drug resistance (primary and acquired)","route":"/terms/resistance/"}],"journal":[{"id":"nature-communications","kind":"journal","name":"Nature Communications","route":"/journals/nature-communications/"}],"pathway":[{"id":"theories-of-cancer","kind":"pathway","name":"Theories of cancer: how the ideas connect","route":"/pathways/theories-of-cancer/"}]}}