{"entity":{"id":"robbie-majzner","kind":"person","name":"Robbie G. Majzner","aka":[],"tldr":"Led the GD2 CAR-T trial in diffuse midline glioma and defined antigen density as a barrier to CAR-T in solid tumours.","summary":"Robbie Majzner was first author of the Nature trial of GD2-directed CAR T cells in H3K27M-mutant diffuse midline glioma, one of the first cell therapies to show activity in a paediatric brain tumour, and led the work showing CAR T cells need high antigen density and that B7-H3 is a broadly expressed paediatric target. He moved from Stanford to lead solid tumour immunotherapy at St. Jude.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Majzner%20RG%5BAuthor%5D%20CAR%20T"}],"tags":["cell-therapy","car-t","paediatric"],"related":[],"cancers":["neuroblastoma","osteosarcoma"],"sections":[],"technologies":["car-t","armored-car"],"targets":["b7h3"],"drugs":[],"companies":[],"institutions":["st-jude"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Director of Solid Tumor Immunotherapy, Department of Oncology, St. Jude Children's Research Hospital","institutionId":"st-jude","specialisms":["Paediatric CAR T-cell therapy","Solid tumour immunotherapy","GD2 and B7-H3 targets","CAR engineering"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Majzner%20RG%5BAuthor%5D%20CAR%20T"}],"papers":[{"title":"GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas","journal":"Nature","year":2022,"doi":"10.1038/s41586-022-04489-4"},{"title":"Tuning the antigen density requirement for CAR T-cell activity","journal":"Cancer Discovery","year":2020,"doi":"10.1158/2159-8290.CD-19-0945"}]},"route":"/people/robbie-majzner/","neighbours":{"cancer":[{"id":"neuroblastoma","kind":"cancer","name":"Neuroblastoma (paediatric)","route":"/cancers/neuroblastoma/"},{"id":"osteosarcoma","kind":"cancer","name":"Osteosarcoma","route":"/cancers/osteosarcoma/"}],"technology":[{"id":"armored-car","kind":"technology","name":"Armoured, logic-gated & next-gen CARs","route":"/technologies/armored-car/"},{"id":"car-t","kind":"technology","name":"CAR-T cell therapy","route":"/technologies/car-t/"}],"target":[{"id":"b7h3","kind":"target","name":"B7-H3","route":"/targets/b7h3/"}],"institution":[{"id":"st-jude","kind":"institution","name":"St. Jude Children's Research Hospital","route":"/institutions/st-jude/"}]}}