{"entity":{"id":"rictor","kind":"target","name":"RICTOR","aka":["RPTOR independent companion of MTOR complex 2","Rapamycin-insensitive companion of mTOR","MGC39830","AVO3","KIAA1999"],"tldr":"RICTOR (Rapamycin-insensitive companion of mTOR) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer, Lung cancer, Breast cancer and 5 more.","summary":"Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organisation, lipogenesis and anabolic output. In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1. In contrast to mTORC1, mTORC2 is nutrient-insensitive.\n\nCIViC holds 4 clinical evidence items and 0 assertions across 1 variant, naming Vistusertib, Sapanisertib, MTOR Kinase Inhibitor AZD8055 and Onatasertib. Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.61, genetic association 0.00, somatic mutation 0.98).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:28611","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28611"},{"label":"UniProt Q6R327","url":"https://www.uniprot.org/uniprotkb/Q6R327/entry"},{"label":"NCBI Gene 253260","url":"https://www.ncbi.nlm.nih.gov/gene/253260"},{"label":"Ensembl ENSG00000164327","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000164327"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["gastric","lung-cancer","breast-cancer","skin-cancer","colorectal","sclc","nsclc","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 4 therapies; CIViC holds 4 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RICTOR","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:28611","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28611","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q6R327","url":"https://www.uniprot.org/uniprotkb/Q6R327/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene RICTOR","url":"https://civicdb.org/features/20480","note":"4 evidence items, 0 assertions, 1 variants; diseases: Lung Small Cell Carcinoma, Lung Adenocarcinoma, Gastric Adenocarcinoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000164327","url":"https://platform.opentargets.org/target/ENSG00000164327/associations","note":"association with cancer (MONDO_0004992) 0.66; per-cancer scores at or above 0.5: colorectal cancer 0.50, gastric cancer 0.51, melanoma 0.54, skin cancer 0.52, breast cancer 0.54, lung cancer 0.57 (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"many-types","specificityNote":"Broadly expressed or essential: HPA lists RICTOR among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA RICTOR: RNA low tissue specificity; blood lineage lineage enriched (granulocytes 31 nTPM); high antibody staining in 14 normal tissues; highest cancer staining endometrial cancer (5 of 11 high). Distribution: 5 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Gastric & gastro-oesophageal junction cancer, Lung cancer (all types), Breast cancer (all types), Skin cancer (all types), Colorectal cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas RICTOR tissue","url":"https://www.proteinatlas.org/ENSG00000164327-RICTOR/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000164327 associations","url":"https://platform.opentargets.org/target/ENSG00000164327/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:28611","ensembl":"ENSG00000164327","uniprot":"Q6R327","entrez":"253260","firstDescribed":2002,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Ohara et al, DNA Res, 2002, \"Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/12056414/","biology":"Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organisation, lipogenesis and anabolic output. In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1. In contrast to mTORC1, mTORC2 is nutrient-insensitive. Within the mTORC2 complex, RICTOR probably acts as a molecular adapter. RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2. mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation. mTORC2 catalyses the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657'. The mTORC2 complex also phosphorylates various proteins involved in insulin signalling, such as FBXW8 and IGF2BP1. mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibres or F-actin. Location: Cell membrane; Endoplasmic reticulum membrane; Lysosome membrane (UniProt). Locus 5p13.1 (HGNC).","whereFound":["Gastric & gastro-oesophageal junction cancer: Open Targets association 0.51 with gastric cancer (MONDO_0001056); CIViC evidence names this disease","Lung cancer: Open Targets association 0.57 with lung cancer (MONDO_0008903)","Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)","Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)","Colorectal cancer: Open Targets association 0.50 with colorectal cancer (MONDO_0005575)","Small-cell lung cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/rictor/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}]}}