{"entity":{"id":"reinhard-buettner","kind":"person","name":"Reinhard Büttner","aka":[],"tldr":"Molecular pathologist who co-founded Network Genomic Medicine and characterised lung cancer genomes.","summary":"Reinhard Büttner is Director of the Institute of Pathology at University Hospital Cologne (CIO). A molecular pathologist, his specialisms are molecular pathology, lung cancer genomics and predictive biomarkers, combining histopathology and immunohistochemistry with comprehensive genomic profiling. He co-founded Network Genomic Medicine and co-authored the Clinical Lung Cancer Genome Project analyses that defined targetable alterations in non-small-cell lung cancer. His papers include a review of PD-L1 immunohistochemistry assays and their clinical implementation in lung cancer, a study of KEAP1- and NFE2L2-mutated non-small-cell lung carcinoma, and a review of precision medicine in non-small-cell lung cancer. His publications are listed on PubMed.","asOf":"2026-09-08","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Buttner%20R%5BAuthor%5D%20lung%20cancer%20genome"}],"tags":[],"related":[],"cancers":["nsclc"],"sections":[],"technologies":["histopathology-ihc","cgp"],"targets":[],"drugs":[],"companies":[],"institutions":["uniklinik-koeln"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["seminars-in-cancer-biology"],"dependsOn":[],"notes":[],"role":"Director, Institute of Pathology, University Hospital Cologne","institutionId":"uniklinik-koeln","specialisms":["Molecular pathology","Lung cancer genomics","Predictive biomarkers"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Buttner%20R%5BAuthor%5D%20lung%20cancer%20genome"}],"papers":[{"title":"Programmed Death-Ligand 1 Immunohistochemistry Testing: A Review of Analytical Assays and Clinical Implementation in Non–Small-Cell Lung Cancer","journal":"Journal of Clinical Oncology","year":2017,"doi":"10.1200/jco.2017.74.7642"},{"title":"Clinical and Pathological Characteristics of KEAP1 - and NFE2L2 -Mutated Non–Small Cell Lung Carcinoma (NSCLC)","journal":"Clinical Cancer Research","year":2018,"doi":"10.1158/1078-0432.ccr-17-3416"},{"title":"Precision medicine in non-small cell lung cancer: Current applications and future directions","journal":"Seminars in Cancer Biology","year":2022,"doi":"10.1016/j.semcancer.2020.07.009"}]},"route":"/people/reinhard-buettner/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"technology":[{"id":"cgp","kind":"technology","name":"Comprehensive genomic profiling","route":"/technologies/cgp/"},{"id":"histopathology-ihc","kind":"technology","name":"Histopathology & immunohistochemistry","route":"/technologies/histopathology-ihc/"}],"institution":[{"id":"nngm","kind":"institution","name":"nationales Netzwerk Genomische Medizin Lungenkrebs","route":"/institutions/nngm/"},{"id":"uniklinik-koeln","kind":"institution","name":"Uniklinik Köln (CIO)","route":"/institutions/uniklinik-koeln/"}],"journal":[{"id":"seminars-in-cancer-biology","kind":"journal","name":"Seminars in cancer biology","route":"/journals/seminars-in-cancer-biology/"}]}}