{"entity":{"id":"regina-barzilay","kind":"person","name":"Regina Barzilay","aka":[],"tldr":"Computer scientist who built Mirai and Sybil, AI models that predict breast and lung cancer risk years before diagnosis.","summary":"Regina Barzilay, a breast cancer survivor, led the development of Mirai, which predicts five-year breast cancer risk from mammograms, and Sybil, which predicts six-year lung cancer risk from a single low-dose CT, both validated across international cohorts and now in prospective trials. Her group also uses machine learning for antibiotic and drug discovery. She received the inaugural AAAI Squirrel AI Award and a MacArthur Fellowship.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Barzilay%20R%5BAuthor%5D%20deep%20learning%20cancer%20risk"}],"tags":["ai","risk-prediction","screening"],"related":[],"cancers":["breast-hr-positive","nsclc"],"sections":[],"technologies":["radiology-ai-screening","ai-drug-design"],"targets":[],"drugs":[],"companies":[],"institutions":["mit-koch"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"School of Engineering Distinguished Professor for AI and Health, MIT; AI Faculty Lead, Jameel Clinic","institutionId":"mit-koch","specialisms":["Machine learning for oncology","AI risk prediction from imaging","Drug discovery AI","Natural language processing"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Barzilay%20R%5BAuthor%5D%20deep%20learning%20cancer%20risk"}],"papers":[{"title":"Toward robust mammography-based models for breast cancer risk (Mirai)","journal":"Science Translational Medicine","year":2021,"doi":"10.1126/scitranslmed.aba4373"},{"title":"Sybil: a validated deep learning model to predict future lung cancer risk from a single low-dose chest computed tomography","journal":"JCO","year":2023,"doi":"10.1200/JCO.22.01345"}]},"route":"/people/regina-barzilay/","neighbours":{"cancer":[{"id":"breast-hr-positive","kind":"cancer","name":"HR-positive / HER2-negative breast cancer","route":"/cancers/breast-hr-positive/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"technology":[{"id":"radiology-ai-screening","kind":"technology","name":"AI in radiology","route":"/technologies/radiology-ai-screening/"},{"id":"ai-drug-design","kind":"technology","name":"AI-driven drug & target discovery","route":"/technologies/ai-drug-design/"}],"institution":[{"id":"mit-koch","kind":"institution","name":"David H. Koch Institute for Integrative Cancer Research at MIT","route":"/institutions/mit-koch/"}]}}