{"entity":{"id":"reflexion","kind":"company","name":"RefleXion Medical","aka":[],"tldr":"RefleXion Medical makes the first PET-guided radiotherapy system, which uses the tumour's own emissions to steer the beam.","summary":"RefleXion Medical, based in Hayward, California, makes the first PET-guided radiotherapy system, which uses the tumour's own positron emissions to steer the treatment beam. Its SCINTIX biology-guided radiotherapy received FDA authorisation in 2023 for lung and bone metastases. OnCo links it to MR-guided adaptive radiotherapy and PET as technologies, to the molecular imaging roadmap from FDG through PSMA and FAP to immune PET, to the bottleneck that surgery and radiotherapy cure most patients but get least funding, and to the idea of coverage-with-evidence registries for adaptive radiotherapy. Whether tracking tumours by their own signal allows safe treatment of many metastases at once is the open question the system was built to test. The radiotherapy technology pages carry the evidence.","asOf":"2026-09-04","links":[{"label":"Official website","url":"https://reflexion.com"}],"tags":[],"related":[],"cancers":[],"sections":["radiation"],"technologies":["mr-linac","pet"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"hq":"Hayward, CA","country":"US","companyType":"devices","website":"https://reflexion.com","investors":[],"funding":[]},"route":"/companies/reflexion/","neighbours":{"section":[{"id":"radiation","kind":"section","name":"Radiation Therapy","route":"/fronts/radiation/"}],"technology":[{"id":"biology-guided-radiotherapy","kind":"technology","name":"Biology-guided radiotherapy (RefleXion X1, SCINTIX)","route":"/technologies/biology-guided-radiotherapy/"},{"id":"radiotherapy-equipment-manufacturing","kind":"technology","name":"Linac, proton system and brachytherapy machine manufacturing","route":"/technologies/radiotherapy-equipment-manufacturing/"},{"id":"mr-linac","kind":"technology","name":"MR-guided adaptive radiotherapy","route":"/technologies/mr-linac/"},{"id":"pet","kind":"technology","name":"PET (positron emission tomography)","route":"/technologies/pet/"}],"roadmap":[{"id":"molecular-imaging-roadmap","kind":"roadmap","name":"Molecular imaging roadmap: FDG → PSMA → FAP → antigen and immune PET","route":"/roadmaps/molecular-imaging-roadmap/"},{"id":"radiation-roadmap","kind":"roadmap","name":"Radiotherapy roadmap: X-rays → shaped beams → fewer fractions, particles and FLASH","route":"/roadmaps/radiation-roadmap/"}],"bottleneck":[{"id":"b-surgery-radiation-innovation","kind":"bottleneck","name":"Surgery and radiotherapy cure most, get least","route":"/bottlenecks/b-surgery-radiation-innovation/"}],"idea":[{"id":"idea-fund-adaptive-radiotherapy-evidence","kind":"idea","name":"Coverage-with-evidence registries for MR-guided and adaptive radiotherapy","route":"/ideas/idea-fund-adaptive-radiotherapy-evidence/"}]}}