{"entity":{"id":"razelle-kurzrock","kind":"person","name":"Razelle Kurzrock","aka":[],"tldr":"Precision oncology pioneer who showed that matching drugs to each patient's mutations, in combination, improves outcomes.","summary":"Razelle Kurzrock (Medical College of Wisconsin; formerly MD Anderson and UC San Diego) built one of the first large precision oncology programmes and led the I-PREDICT trial, which showed that individualised combination therapy matched to a higher fraction of a tumour's alterations improves progression-free survival. She founded the WIN Consortium and the field's methodology for N-of-1 matching, and has led early-phase trials in rare and refractory cancers.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Kurzrock%20R%5BAuthor%5D%20precision%20oncology%20matched"}],"tags":["precision-oncology","early-phase","n-of-1"],"related":[],"cancers":[],"sections":[],"technologies":["cgp","ai-trial-matching"],"targets":[],"drugs":[],"companies":[],"institutions":["mcw-cancer-center"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Professor of Medicine, Medical College of Wisconsin; Linda T. and John A. Mellowes Endowed Chair in Precision Oncology","institutionId":"mcw-cancer-center","specialisms":["Precision oncology","Early-phase trials","N-of-1 combination therapy","Rare cancers"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Kurzrock%20R%5BAuthor%5D%20precision%20oncology%20matched"}],"papers":[{"title":"Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study","journal":"Nature Medicine","year":2019,"doi":"10.1038/s41591-019-0407-5"},{"title":"Personalized medicine in a phase I clinical trials program: the MD Anderson Cancer Center initiative","journal":"Clinical Cancer Research","year":2012,"doi":"10.1158/1078-0432.CCR-12-1627"}]},"route":"/people/razelle-kurzrock/","neighbours":{"technology":[{"id":"ai-trial-matching","kind":"technology","name":"AI trial matching & clinical decision support","route":"/technologies/ai-trial-matching/"},{"id":"cgp","kind":"technology","name":"Comprehensive genomic profiling","route":"/technologies/cgp/"}],"institution":[{"id":"mcw-cancer-center","kind":"institution","name":"Medical College of Wisconsin Cancer Center","route":"/institutions/mcw-cancer-center/"}],"term":[{"id":"master-protocol","kind":"term","name":"Master protocol (platform, basket and umbrella trials)","route":"/terms/master-protocol/"}],"trial":[{"id":"dart-s1609","kind":"trial","name":"DART (SWOG S1609): nivolumab plus ipilimumab in rare tumours","route":"/trials/dart-s1609/"},{"id":"i-predict","kind":"trial","name":"I-PREDICT","route":"/trials/i-predict/"},{"id":"winther","kind":"trial","name":"WINTHER","route":"/trials/winther/"}]}}