{"entity":{"id":"raffit-hassan","kind":"person","name":"Raffit Hassan","aka":[],"tldr":"Made mesothelin a drug target, from immunotoxins to ADCs and CAR-T, and leads NCI's mesothelioma programme.","summary":"Raffit Hassan is Chief of the Thoracic and GI Malignancies Branch at the National Cancer Institute. He is a thoracic oncologist known for making mesothelin a drug target, with work on mesothelin biology and mesothelin-directed agents including the immunotoxins SS1P and LMB-100 and the antibody-drug conjugate anetumab. His selected paper asks whether mesothelin immunotherapy for cancer is ready for prime time. He leads NCI's mesothelioma programme, and his work underpins current CAR-T and ADC efforts in mesothelioma and pancreatic cancer.","asOf":"2026-09-08","links":[{"label":"NCI CCR profile","url":"https://ccr.cancer.gov/staff-directory/raffit-hassan"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Hassan%20R%5BAuthor%5D"}],"tags":[],"related":[],"cancers":["mesothelioma","pancreatic"],"sections":[],"technologies":[],"targets":["mesothelin"],"drugs":[],"companies":[],"institutions":["nci"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Chief, Thoracic and GI Malignancies Branch","institutionId":"nci","specialisms":["Mesothelioma","Mesothelin-targeted therapy","Immunotoxins"],"profiles":[{"label":"NCI CCR profile","url":"https://ccr.cancer.gov/staff-directory/raffit-hassan"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Hassan%20R%5BAuthor%5D"}],"papers":[{"title":"Mesothelin immunotherapy for cancer: ready for prime time?","journal":"Journal of Clinical Oncology","year":2016}]},"route":"/people/raffit-hassan/","neighbours":{"cancer":[{"id":"mesothelioma","kind":"cancer","name":"Mesothelioma","route":"/cancers/mesothelioma/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}],"target":[{"id":"mesothelin","kind":"target","name":"Mesothelin","route":"/targets/mesothelin/"}],"institution":[{"id":"nci","kind":"institution","name":"National Cancer Institute (NIH)","route":"/institutions/nci/"},{"id":"nci-ccr","kind":"institution","name":"NCI Center for Cancer Research (intramural programme)","route":"/institutions/nci-ccr/"}]}}