{"entity":{"id":"quality-of-life","kind":"term","name":"Quality of life","aka":["QoL","HRQoL","health-related quality of life","patient-reported outcomes","patient-reported outcome","PROs","PRO","patient-reported","symptom burden","functional status","performance status","ECOG","ECOG 0-1","ECOG performance status","Karnofsky","time to deterioration","wellbeing"],"tldr":"How a patient actually feels and functions day to day: symptoms, energy, mood, ability to work and live normally. Measured with questionnaires, it is the outcome that matters most alongside survival, and the one trials have historically neglected.","summary":"Standard instruments (EORTC QLQ-C30, FACT-G, EQ-5D) ask patients to rate pain, fatigue, nausea, physical and social function, and are collected repeatedly during a trial; results are reported as change from baseline or time until quality of life deteriorates. They matter because a drug that extends progression-free survival by two months while making patients feel worse may not be a good trade, and because regulators and health systems increasingly weigh them in approval and pricing. Performance status (ECOG 0 to 4) is the clinician's brief summary of how well a patient functions and gates who is fit enough for treatment and for trials.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Quality_of_life_(healthcare)","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Quality_of_life_(healthcare)"}],"tags":[],"related":["side-effect-vs-adverse-event","toxicity-grade","palliative-treatment","endpoint","financial-toxicity"],"cancers":[],"sections":[],"technologies":["geriatric-assessment"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":["paper-cella-fact-g-jco-1993"],"journals":[],"dependsOn":[],"notes":[],"category":"Clinic basics"},"route":"/terms/quality-of-life/","neighbours":{"term":[{"id":"bipolar-androgen-therapy","kind":"term","name":"Bipolar androgen therapy 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