{"entity":{"id":"ptprf","kind":"target","name":"PTPRF","aka":["protein tyrosine phosphatase receptor type F","Receptor-type tyrosine-protein phosphatase F"],"tldr":"PTPRF (Receptor-type tyrosine-protein phosphatase F) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.","summary":"Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Erlotinib Hydrochloride.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9670","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9670"},{"label":"UniProt P10586","url":"https://www.uniprot.org/uniprotkb/P10586/entry"},{"label":"NCBI Gene 5792","url":"https://www.ncbi.nlm.nih.gov/gene/5792"},{"label":"Ensembl ENSG00000142949","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000142949"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PTPRF","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:9670","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9670","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P10586","url":"https://www.uniprot.org/uniprotkb/P10586/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene PTPRF","url":"https://civicdb.org/features/4695","note":"2 evidence items, 0 assertions, 1 variants; diseases: Lung Non-small Cell Carcinoma (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA PTPRF: RNA low tissue specificity; no normal tissue stained high; highest cancer staining endometrial cancer (3 of 11 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas PTPRF tissue","url":"https://www.proteinatlas.org/ENSG00000142949-PTPRF/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000142949 associations","url":"https://platform.opentargets.org/target/ENSG00000142949/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:9670","ensembl":"ENSG00000142949","uniprot":"P10586","entrez":"5792","firstDescribed":1988,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Streuli et al, J. Exp. Med, 1988, \"A new member of the immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/2972792/","biology":"Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Location: Membrane (UniProt). Locus 1p34.2 (HGNC).","whereFound":["Non-small-cell lung cancer: CIViC evidence names this disease"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/ptprf/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}