{"entity":{"id":"ptprd","kind":"target","name":"PTPRD","aka":["protein tyrosine phosphatase receptor type D","Receptor-type tyrosine-protein phosphatase delta"],"tldr":"PTPRD (Receptor-type tyrosine-protein phosphatase delta) is an enzyme. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Oesophageal cancer, Non-Hodgkin lymphoma and 5 more.","summary":"Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2.\n\nCIViC holds 4 clinical evidence items and 0 assertions across 5 variants, naming Temsirolimus, IGF1R Monoclonal Antibody, JSI-124 and Teprotumumab and others. IntOGen calls it a driver in 12 cohorts (8 activating, 4 loss-of-function), covering Invasive Breast Carcinoma, Oesophagogastric Adenocarcinoma, Oesophageal Adenocarcinoma, Oesophageal Squamous Cell Carcinoma, Lymphoid Neoplasm, Melanoma and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9668","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9668"},{"label":"UniProt P23468","url":"https://www.uniprot.org/uniprotkb/P23468/entry"},{"label":"NCBI Gene 5789","url":"https://www.ncbi.nlm.nih.gov/gene/5789"},{"label":"Ensembl ENSG00000153707","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000153707"}],"tags":["cancer-genes-wave"],"related":["civic","intogen"],"cancers":["breast-cancer","esophageal","non-hodgkin-lymphoma","gastric","ovarian","pancreatic","small-bowel","ewing-sarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 5 therapies; IntOGen calls it an activating (Act) driver in 8 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 4 cohorts; CIViC holds 4 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Head And Neck Carcinoma; Ewing Sarcoma Of Bone."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PTPRD","role":["drug-target","oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:9668","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9668","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P23468","url":"https://www.uniprot.org/uniprotkb/P23468/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene PTPRD","url":"https://civicdb.org/features/4692","note":"4 evidence items, 0 assertions, 5 variants; diseases: Ewing Sarcoma, Head And Neck Carcinoma, Ewing Sarcoma Of Bone (GraphQL API, CC0)"},{"label":"IntOGen PTPRD","url":"https://www.intogen.org/search?gene=PTPRD","note":"driver in 12 cohorts (Act 8, LoF 4); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificity":"tumour-specific","distribution":"many-types","specificityNote":"Tumour-specific alteration: the catalogues call it an oncogene driver (IntOGen cohort analysis finds it activated more often than chance) and a tumour suppressor (IntOGen finds it knocked out more often than chance), so the direction differs between cohorts but the alteration is somatic either way; what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA PTPRD: RNA tissue enhanced (brain 39 nTPM, parathyroid gland 17 nTPM); no normal tissue stained high; highest cancer staining lymphoma (1 of 12 high). Distribution: 8 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Breast cancer (all types), Oesophageal cancer, Lymphoma, Gastric & gastro-oesophageal junction cancer, Ovarian cancer, Pancreatic ductal adenocarcinoma, Small intestine cancer (small bowel adenocarcinoma) and more); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 6 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"UniProt P23468","url":"https://www.uniprot.org/uniprotkb/P23468/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene PTPRD","url":"https://civicdb.org/features/4692","note":"4 evidence items, 0 assertions, 5 variants; diseases: Ewing Sarcoma, Head And Neck Carcinoma, Ewing Sarcoma Of Bone (GraphQL API, CC0)"},{"label":"IntOGen PTPRD","url":"https://www.intogen.org/search?gene=PTPRD","note":"driver in 12 cohorts (Act 8, LoF 4); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"},{"label":"Human Protein Atlas PTPRD tissue","url":"https://www.proteinatlas.org/ENSG00000153707-PTPRD/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000153707 associations","url":"https://platform.opentargets.org/target/ENSG00000153707/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:9668","ensembl":"ENSG00000153707","uniprot":"P23468","entrez":"5789","firstDescribed":1990,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Krueger N.X. et al, EMBO J, 1990, \"Structural diversity and evolution of human receptor-like protein tyrosine phosphatases\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/2170109/","biology":"Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2. Location: Membrane (UniProt). Locus 9p24.1-p23 (HGNC).","whereFound":["Breast cancer: IntOGen driver in 2 cohorts (BRCA)","Oesophageal cancer: IntOGen driver in 2 cohorts (ESCA, ESCC)","Non-Hodgkin lymphoma: IntOGen driver in 2 cohorts (LNM, NHL)","Gastric & gastro-oesophageal junction cancer: IntOGen driver in 1 cohort (EGC)","Ovarian cancer: IntOGen driver in 1 cohort (OVT)","Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/ptprd/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"ewing-sarcoma","kind":"cancer","name":"Ewing sarcoma","route":"/cancers/ewing-sarcoma/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"small-bowel","kind":"cancer","name":"Small intestine cancer (small bowel adenocarcinoma)","route":"/cancers/small-bowel/"}]}}