{"entity":{"id":"ptprb","kind":"target","name":"PTPRB","aka":["protein tyrosine phosphatase receptor type B","Receptor-type tyrosine-protein phosphatase beta"],"tldr":"PTPRB (Receptor-type tyrosine-protein phosphatase beta) is an enzyme. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer, Mesothelioma, Skin cancer and 5 more.","summary":"Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2.\n\nCIViC holds 4 clinical evidence items and 0 assertions across 3 variants, naming Sunitinib and Vatalanib. Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.80, genetic association 0.03, somatic mutation 0.92). IntOGen calls it a driver in 6 cohorts (1 activating, 5 loss-of-function), covering Angiosarcoma, Melanoma, Ovarian Epithelial Tumour, Pleural Mesothelioma, Thymoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9665","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9665"},{"label":"UniProt P23467","url":"https://www.uniprot.org/uniprotkb/P23467/entry"},{"label":"NCBI Gene 5787","url":"https://www.ncbi.nlm.nih.gov/gene/5787"},{"label":"Ensembl ENSG00000127329","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000127329"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["ovarian","mesothelioma","skin-cancer","lung-cancer","sarcoma","breast-cancer","angiosarcoma","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 5 cohorts; CIViC holds 4 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PTPRB","role":["drug-target","oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:9665","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9665","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P23467","url":"https://www.uniprot.org/uniprotkb/P23467/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene PTPRB","url":"https://civicdb.org/features/4690","note":"4 evidence items, 0 assertions, 3 variants; diseases: Angiosarcoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000127329","url":"https://platform.opentargets.org/target/ENSG00000127329/associations","note":"association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: melanoma 0.59, sarcoma 0.52, skin cancer 0.57, breast cancer 0.52, lung cancer 0.53 (GraphQL API, CC0)"},{"label":"IntOGen PTPRB","url":"https://www.intogen.org/search?gene=PTPRB","note":"driver in 6 cohorts (Act 1, LoF 5); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificity":"tumour-specific","distribution":"many-types","specificityNote":"Tumour-specific alteration: the catalogues call it an oncogene driver (IntOGen cohort analysis finds it activated more often than chance) and a tumour suppressor (IntOGen finds it knocked out more often than chance), so the direction differs between cohorts but the alteration is somatic either way; what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA PTPRB: RNA low tissue specificity; no normal tissue stained high; highest cancer staining prostate cancer (11 of 12 high). Distribution: 6 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Ovarian cancer, Mesothelioma, Skin cancer (all types), Lung cancer (all types), Sarcomas (soft tissue, bone, GIST), Breast cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 6 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"UniProt P23467","url":"https://www.uniprot.org/uniprotkb/P23467/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene PTPRB","url":"https://civicdb.org/features/4690","note":"4 evidence items, 0 assertions, 3 variants; diseases: Angiosarcoma (GraphQL API, CC0)"},{"label":"IntOGen PTPRB","url":"https://www.intogen.org/search?gene=PTPRB","note":"driver in 6 cohorts (Act 1, LoF 5); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"},{"label":"Human Protein Atlas PTPRB tissue","url":"https://www.proteinatlas.org/ENSG00000127329-PTPRB/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000127329 associations","url":"https://platform.opentargets.org/target/ENSG00000127329/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:9665","ensembl":"ENSG00000127329","uniprot":"P23467","entrez":"5787","firstDescribed":1990,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Krueger N.X. et al, EMBO J, 1990, \"Structural diversity and evolution of human receptor-like protein tyrosine phosphatases\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/2170109/","biology":"Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signalling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin. Location: Membrane (UniProt). Locus 12q15 (HGNC).","whereFound":["Ovarian cancer: IntOGen driver in 2 cohorts (OVT)","Mesothelioma: IntOGen driver in 1 cohort (PLMESO)","Skin cancer: Open Targets association 0.57 with skin cancer (MONDO_0002898)","Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903)","Sarcomas: Open Targets association 0.52 with sarcoma (MONDO_0005089)","Breast cancer: Open Targets association 0.52 with breast cancer (MONDO_0007254)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/ptprb/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"angiosarcoma","kind":"cancer","name":"Angiosarcoma","route":"/cancers/angiosarcoma/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"mesothelioma","kind":"cancer","name":"Mesothelioma","route":"/cancers/mesothelioma/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}