{"entity":{"id":"prune2","kind":"target","name":"PRUNE2","aka":["prune homolog 2 with BCH domain","Protein prune homolog 2","BMCC1","BNIPXL","A214N16.3","bA214N16.3","C9orf65","KIAA0367"],"tldr":"PRUNE2 (Protein prune homolog 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Neuroblastoma.","summary":"May play an important role in regulating differentiation, survival and aggressiveness of the tumour cells.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Neuroblastoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:25209","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25209"},{"label":"UniProt Q8WUY3","url":"https://www.uniprot.org/uniprotkb/Q8WUY3/entry"},{"label":"NCBI Gene 158471","url":"https://www.ncbi.nlm.nih.gov/gene/158471"},{"label":"Ensembl ENSG00000106772","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000106772"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["neuroblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PRUNE2","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:25209","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25209","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8WUY3","url":"https://www.uniprot.org/uniprotkb/Q8WUY3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen PRUNE2","url":"https://www.intogen.org/search?gene=PRUNE2","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificitySources":[],"hgnc":"HGNC:25209","ensembl":"ENSG00000106772","uniprot":"Q8WUY3","entrez":"158471","firstDescribed":1997,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1997, \"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/9205841/","biology":"May play an important role in regulating differentiation, survival and aggressiveness of the tumour cells. Location: Cytoplasm (UniProt). Locus 9q21.2 (HGNC).","whereFound":["Neuroblastoma: IntOGen driver in 1 cohort (NBL)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/prune2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"neuroblastoma","kind":"cancer","name":"Neuroblastoma (paediatric)","route":"/cancers/neuroblastoma/"}]}}