{"entity":{"id":"proteomics-platforms","kind":"technology","name":"Proteomics instruments and affinity platforms","aka":[],"tldr":"Machines that measure thousands of proteins at once from tissue or blood, used to find drug targets and early-detection markers.","summary":"Mass spectrometry (Thermo Fisher Orbitrap Astral, Bruker timsTOF, SCIEX ZenoTOF) and affinity-based platforms (Olink/Thermo Fisher Explore, SomaLogic/Standard BioTools SomaScan, Alamar NULISA, Nautilus and Quantum-Si single-molecule approaches) deliver deep proteomes; UK Biobank's 50,000-participant Olink dataset and CPTAC's tumour proteogenomics illustrate the discovery value. Clinical proteomic tests remain few.","status":"established","asOf":"2026-09-08","links":[{"label":"Method of the Year 2012: targeted proteomics (Nature Methods 2013)","url":"https://doi.org/10.1038/nmeth.2329"}],"tags":["supporting"],"related":["uk-biobank"],"cancers":[],"sections":["drug-discovery","diagnostics"],"technologies":["proteomics","liquid-biopsy"],"targets":[],"drugs":[],"companies":["thermo-fisher","bruker","standard-biotools"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":["paper-authors-nat-methods"],"journals":[],"dependsOn":[],"notes":[],"principle":"Peptide fragmentation and mass measurement (bottom-up MS) or barcoded antibody/aptamer pairs read by sequencing or PCR quantify proteins across large dynamic ranges.","strengths":["Direct measurement of drug targets and post-translational state","Plasma proteomics at biobank scale"],"limitations":["Cost per sample","Dynamic range and low-abundance proteins","Standardisation across platforms"]},"route":"/technologies/proteomics-platforms/","neighbours":{"collection":[{"id":"uk-biobank","kind":"collection","name":"UK Biobank","route":"/collections/uk-biobank/"}],"section":[{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"},{"id":"drug-discovery","kind":"section","name":"Drug Discovery Platforms","route":"/fronts/drug-discovery/"}],"technology":[{"id":"liquid-biopsy","kind":"technology","name":"Liquid biopsy (ctDNA)","route":"/technologies/liquid-biopsy/"},{"id":"proteomics","kind":"technology","name":"Proteomics & phosphoproteomics","route":"/technologies/proteomics/"}],"company":[{"id":"bruker","kind":"company","name":"Bruker (Bruker Spatial Biology)","route":"/companies/bruker/"},{"id":"fujirebio","kind":"company","name":"Fujirebio","route":"/companies/fujirebio/"},{"id":"standard-biotools","kind":"company","name":"Standard BioTools (SomaLogic)","route":"/companies/standard-biotools/"},{"id":"thermo-fisher","kind":"company","name":"Thermo Fisher Scientific","route":"/companies/thermo-fisher/"}],"paper":[{"id":"paper-authors-nat-methods","kind":"paper","name":"Method of the Year 2012","route":"/key-papers/paper-authors-nat-methods/"}],"term":[{"id":"mass-spec-proteome","kind":"term","name":"Deep mass-spectrometry proteome (CPTAC)","route":"/terms/mass-spec-proteome/"}]}}