{"entity":{"id":"prncr1","kind":"target","name":"PRNCR1","aka":["prostate cancer associated non-coding RNA 1","PCAT8"],"tldr":"PRNCR1 (prostate cancer associated non-coding RNA 1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.","summary":"UniProt has no function text for this gene; HGNC names it \"prostate cancer associated non-coding RNA 1\".\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:48942","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:48942"},{"label":"NCBI Gene 101867536","url":"https://www.ncbi.nlm.nih.gov/gene/101867536"},{"label":"Ensembl ENSG00000282961","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000282961"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PRNCR1","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:48942","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:48942","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"CIViC gene PRNCR1","url":"https://civicdb.org/features/41522","note":"1 evidence items, 0 assertions, 1 variants; diseases: Colorectal Cancer (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: the Human Protein Atlas has no row for PRNCR1 and no corpus medicine is aimed at it. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Colorectal cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Open Targets ENSG00000282961 associations","url":"https://platform.opentargets.org/target/ENSG00000282961/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:48942","ensembl":"ENSG00000282961","entrez":"101867536","biology":"UniProt has no function text for this gene; HGNC names it \"prostate cancer associated non-coding RNA 1\". Locus 8q24.21 (HGNC).","whereFound":["Colorectal cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/prncr1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}