{"entity":{"id":"pole2","kind":"target","name":"POLE2","aka":["DNA polymerase epsilon 2, accessory subunit","DNA polymerase epsilon subunit 2","DPE2"],"tldr":"POLE2 (DNA polymerase epsilon subunit 2) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma, Leukaemia, Lung cancer and 5 more.","summary":"Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication.\n\nOpen Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.93, animal model 0.43, genetic association 0.00, clinical 0.99).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9178","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9178"},{"label":"UniProt P56282","url":"https://www.uniprot.org/uniprotkb/P56282/entry"},{"label":"NCBI Gene 5427","url":"https://www.ncbi.nlm.nih.gov/gene/5427"},{"label":"Ensembl ENSG00000100479","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100479"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["non-hodgkin-lymphoma","leukaemia","lung-cancer","myeloproliferative-neoplasms","breast-cancer","ovarian","mds","all-leukemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.99. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"POLE2","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:9178","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9178","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P56282","url":"https://www.uniprot.org/uniprotkb/P56282/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000100479","url":"https://platform.opentargets.org/target/ENSG00000100479/associations","note":"association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.60, ovarian cancer 0.58, acute myeloid leukaemia 0.59, acute lymphoblastic leukaemia 0.60, B-cell chronic lymphocytic leukaemia 0.59, non-Hodgkin lymphoma 0.61 (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"many-types","specificityNote":"Broadly expressed or essential: HPA lists POLE2 among essential proteins; a medicine acting on the wild-type protein would expose normal tissue too. HPA POLE2: RNA tissue enhanced (bone marrow 17 nTPM); no normal tissue stained high. Distribution: 6 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Lymphoma, Leukaemia, Lung cancer (all types), Myeloid neoplasms, Breast cancer (all types), Ovarian cancer); Open Targets associates it with 10 specific cancer types at or above 0.5 (acute lymphoblastic leukemia, non-small cell lung carcinoma, B-cell chronic lymphocytic leukemia, acute myeloid leukemia, exocrine pancreatic carcinoma, ovarian carcinoma and more). (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas POLE2 tissue","url":"https://www.proteinatlas.org/ENSG00000100479-POLE2/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000100479 associations","url":"https://platform.opentargets.org/target/ENSG00000100479/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:9178","ensembl":"ENSG00000100479","uniprot":"P56282","entrez":"5427","firstDescribed":1997,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Li et al, J. Biol. Chem, 1997, \"Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/9405441/","biology":"Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication. Location: Nucleus (UniProt). Locus 14q21.3 (HGNC).","whereFound":["Non-Hodgkin lymphoma: Open Targets association 0.61 with non-Hodgkin lymphoma (MONDO_0018908)","Leukaemia: Open Targets association 0.61 with leukaemia (MONDO_0005059)","Lung cancer: Open Targets association 0.60 with lung cancer (MONDO_0008903)","Myeloproliferative neoplasms: Open Targets association 0.60 with myeloproliferative neoplasm (MONDO_0020076)","Breast cancer: Open Targets association 0.59 with breast cancer (MONDO_0007254)","Ovarian cancer: Open Targets association 0.58 with ovarian cancer (MONDO_0008170)"],"targetClass":"other","prevalence":[]},"route":"/targets/pole2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"mds","kind":"cancer","name":"Myelodysplastic syndromes / neoplasms (MDS)","route":"/cancers/mds/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}]}}