{"entity":{"id":"pnas","kind":"journal","name":"Proceedings of the National Academy of Sciences","aka":["PNAS","Proc Natl Acad Sci U S A"],"tldr":"PNAS is the US National Academy of Sciences' weekly multidisciplinary journal, free to read six months after publication. Its cancer landmarks include the early oncogene and tumour-suppressor papers, the first PROTAC concept paper and the Iwai and Honjo paper showing that tumours use PD-L1 to escape T cells.","summary":"The Proceedings of the National Academy of Sciences (PNAS) is the multidisciplinary journal of the US National Academy of Sciences, founded in 1915, appearing weekly and available on a hybrid model with free access after six months. It publishes across all sciences, and its cancer landmarks include early oncogene, tumour-suppressor and cancer-evolution modelling papers, mutational-signature methods, and statistical work on cancer risk and screening. Its readers are scientists of every discipline, which is why foundational cancer biology often appeared here. Within OnCo it is the journal of the first PROTAC concept paper and of the Iwai and Honjo paper showing that tumours use PD-L1 to escape T cells, and a reader would use it for foundational cancer biology and modelling work.","asOf":"2026-09-09","links":[{"label":"National Academy of Sciences","url":"https://www.nasonline.org"}],"tags":[],"related":[],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["tumour-suppressor-gene"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"publisher":"National Academy of Sciences","url":"https://www.pnas.org","issn":"0027-8424","scope":"general science","access":"hybrid","founded":1915,"impactFactor":{"value":9.4,"year":2023,"source":"Clarivate Journal Citation Reports 2024 (2023 JIF)"},"matchNames":["PNAS","Proceedings of the National Academy of Sciences","Proceedings of the National Academy of Sciences of the United States of 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retinoblastoma","route":"/key-papers/paper-knudson-proc-natl-acad-sci-u-s-a/"},{"id":"paper-mintz-proc-natl-acad-sci-u-s-a","kind":"paper","name":"Normal genetically mosaic mice produced from malignant teratocarcinoma cells","route":"/key-papers/paper-mintz-proc-natl-acad-sci-u-s-a/"},{"id":"paper-gabai-kapara-population-brca-screening-pnas-2014","kind":"paper","name":"Population-based screening for breast and ovarian cancer risk due to BRCA1 and BRCA2","route":"/key-papers/paper-gabai-kapara-population-brca-screening-pnas-2014/"},{"id":"paper-persson-myb-nfib-pnas-2009","kind":"paper","name":"Recurrent fusion of MYB and NFIB transcription factor genes in adenoid cystic carcinoma","route":"/key-papers/paper-persson-myb-nfib-pnas-2009/"},{"id":"paper-sorlie-repeated-observation-subtypes-brca1-basal-pnas-2003","kind":"paper","name":"Repeated observation of breast tumor subtypes in independent gene expression data 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