{"entity":{"id":"pleura","kind":"term","name":"Pleura","aka":["pleural","pleural cavity","pleural space","extrapleural","pleurectomy","pleurectomy/decortication","pleural metastases"],"tldr":"The two-layered lining around each lung. Mesothelioma grows from it, lung and breast cancers spread to it, and fluid collecting between its layers causes breathlessness.","summary":"The visceral pleura covers the lung and the parietal pleura lines the chest wall; the potential space between them fills with a malignant pleural effusion in advanced lung, breast and ovarian cancers and lymphoma. Malignant pleural mesothelioma, almost always from asbestos, spreads along the pleural surface; its surgery ranges from extrapleural pneumonectomy (abandoned after MARS 1) to pleurectomy/decortication (questioned by MARS 2). Pleural invasion also upstages lung cancer.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Pulmonary_pleurae","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Pulmonary_pleurae"}],"tags":[],"related":["pleural-effusion","pleurodesis","pneumonectomy"],"cancers":["mesothelioma","nsclc"],"sections":["surgery"],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["mars-2"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Anatomy"},"route":"/terms/pleura/","neighbours":{"term":[{"id":"asbestos","kind":"term","name":"Asbestos","route":"/terms/asbestos/"},{"id":"malignant-pleural-effusion","kind":"term","name":"Malignant pleural effusion","route":"/terms/malignant-pleural-effusion/"},{"id":"pleural-effusion","kind":"term","name":"Malignant pleural effusion and ascites","route":"/terms/pleural-effusion/"},{"id":"pleurodesis","kind":"term","name":"Pleurodesis and indwelling pleural catheter","route":"/terms/pleurodesis/"},{"id":"pneumonectomy","kind":"term","name":"Pneumonectomy","route":"/terms/pneumonectomy/"}],"cancer":[{"id":"mesothelioma","kind":"cancer","name":"Mesothelioma","route":"/cancers/mesothelioma/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"section":[{"id":"surgery","kind":"section","name":"Surgery & Interventional","route":"/fronts/surgery/"}],"trial":[{"id":"mars-2","kind":"trial","name":"MARS 2","route":"/trials/mars-2/"}]}}