{"entity":{"id":"pik3cg","kind":"target","name":"PIK3CG","aka":["phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma","Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform"],"tldr":"PIK3CG (Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma, Leukaemia, Acute lymphoblastic leukaemia and 2 more.","summary":"Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signalling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G protein coupled receptor activation to PIP3 production.\n\nOpen Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes clinical 0.67, affected pathway 0.61, literature 0.99, genetic association 0.30, somatic mutation 0.23).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:8978","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8978"},{"label":"UniProt P48736","url":"https://www.uniprot.org/uniprotkb/P48736/entry"},{"label":"NCBI Gene 5294","url":"https://www.ncbi.nlm.nih.gov/gene/5294"},{"label":"Ensembl ENSG00000105851","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000105851"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["non-hodgkin-lymphoma","leukaemia","all-leukemia","cll","follicular-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.95. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PIK3CG","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:8978","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8978","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P48736","url":"https://www.uniprot.org/uniprotkb/P48736/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000105851","url":"https://platform.opentargets.org/target/ENSG00000105851/associations","note":"association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.58, B-cell chronic lymphocytic leukaemia 0.57, non-Hodgkin lymphoma 0.61, follicular lymphoma 0.55, leukaemia 0.58 (GraphQL API, CC0)"}],"distribution":"few-types","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA group enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA PIK3CG: RNA group enriched (bone marrow 41 nTPM, lymphoid tissue 18 nTPM); no normal tissue stained high. Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Lymphoma, Leukaemia); Open Targets associates it with 2 specific cancer types at or above 0.5 (B-cell chronic lymphocytic leukemia, follicular lymphoma). (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas PIK3CG tissue","url":"https://www.proteinatlas.org/ENSG00000105851-PIK3CG/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000105851 associations","url":"https://platform.opentargets.org/target/ENSG00000105851/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:8978","ensembl":"ENSG00000105851","uniprot":"P48736","entrez":"5294","firstDescribed":1995,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Stoyanov et al, Science, 1995, \"Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/7624799/","biology":"Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signalling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarisation and migration by regulating the spatial accumulation of PIP3 and by regulating the organisation of F-actin formation and integrin-based adhesion at the leading edge. Location: Cytoplasm; Cell membrane (UniProt). Locus 7q22.3 (HGNC).","whereFound":["Non-Hodgkin lymphoma: Open Targets association 0.61 with non-Hodgkin lymphoma (MONDO_0018908)","Leukaemia: Open Targets association 0.58 with leukaemia (MONDO_0005059)","Acute lymphoblastic leukaemia: Open Targets association 0.58 with acute lymphoblastic leukaemia (MONDO_0004967)","Chronic lymphocytic leukaemia: Open Targets association 0.57 with B-cell chronic lymphocytic leukaemia (MONDO_0004948)","Follicular lymphoma: Open Targets association 0.55 with follicular lymphoma (MONDO_0018906)"],"targetClass":"kinase","prevalence":[]},"route":"/targets/pik3cg/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"cll","kind":"cancer","name":"Chronic lymphocytic leukaemia","route":"/cancers/cll/"},{"id":"follicular-lymphoma","kind":"cancer","name":"Follicular lymphoma","route":"/cancers/follicular-lymphoma/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}]}}