{"entity":{"id":"pier-giuseppe-pelicci","kind":"person","name":"Pier Giuseppe Pelicci","aka":[],"tldr":"Molecular oncologist who characterised PML-RARα in acute promyelocytic leukaemia and studies cancer stem cells.","summary":"Pier Giuseppe Pelicci is Director of Research at IEO, the European Institute of Oncology, in Milan and Professor at the University of Milan. A molecular oncologist, his specialisms are cancer biology, leukaemia, cancer stem cells and epigenetics. He characterised PML-RARα in acute promyelocytic leukaemia, and his work on that disease, on p66Shc and on stem cell self-renewal made IEO a leading basic research centre. His papers include a Cell Reports study of how p53 loss in breast cancer leads to Myc activation and increased cell plasticity, a study of humanised mice failing to reject human acute myeloid leukaemia cells, and a Nature Communications paper showing caloric restriction expands druggable LSD1-dependent cancer stem cells. His publications are listed on PubMed.","asOf":"2026-09-08","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Pelicci%20PG%5BAuthor%5D%20leukemia"}],"tags":[],"related":[],"cancers":["aml"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["ieo-milan"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Director of Research, IEO; Professor, University of Milan","institutionId":"ieo-milan","specialisms":["Cancer biology","Leukaemia","Cancer stem cells","Epigenetics"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Pelicci%20PG%5BAuthor%5D%20leukemia"}],"papers":[{"title":"p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value","journal":"Cell Reports","year":2019,"doi":"10.1016/j.celrep.2018.12.071"},{"title":"Human cord blood (hCB)-CD34+ humanized mice fail to reject human acute myeloid leukemia cells","journal":"PLOS ONE","year":2019,"doi":"10.1371/journal.pone.0217345"},{"title":"Caloric restriction leads to druggable LSD1-dependent cancer stem cells expansion","journal":"Nature Communications","year":2024,"doi":"10.1038/s41467-023-44348-y"}]},"route":"/people/pier-giuseppe-pelicci/","neighbours":{"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"}],"institution":[{"id":"airc","kind":"institution","name":"Fondazione AIRC per la ricerca sul cancro","route":"/institutions/airc/"},{"id":"ieo-milan","kind":"institution","name":"IEO (European Institute of Oncology)","route":"/institutions/ieo-milan/"}]}}