{"entity":{"id":"penn-abramson","kind":"institution","name":"Abramson Cancer Center, University of Pennsylvania","aka":[],"tldr":"Where CAR-T became a drug (June, Levine; Emily Whitehead), mRNA was made druggable (Karikó, Weissman), and PARP PET was invented.","summary":"The Abramson Cancer Center at the University of Pennsylvania in Philadelphia, NCI-designated as comprehensive, is where CAR-T became a drug through Carl H. June, Bruce L. Levine and the treatment of Emily Whitehead, where Karikó and Drew Weissman made mRNA druggable, recognised by the 2023 Nobel Prize, and where PARP PET was invented. Its record covers CTL019, now tisagenlecleucel, proved in ELIANA and JULIET, the in vivo CAR-T origins behind Capstan and Interius BioTherapeutics, 18F-FluorThanatrace PARP PET, proton therapy and the Basser Center for BRCA, with Robert H. Vonderheide and Robert H. Mach among its people. OnCo links it to CAR-T for glioma, to the PROSE paper on preventive surgery in BRCA carriers, and to Children's Hospital of Philadelphia. Whether in vivo CAR-T can match ex vivo products is the question its spin-outs now test. Programmes are listed below.","asOf":"2026-09-04","links":[{"label":"Official website","url":"https://www.pennmedicine.org/cancer"},{"label":"PTCOG: particle therapy facilities in operation","url":"https://www.ptcog.site/index.php/facilities-in-operation-public"}],"tags":[],"related":[],"cancers":[],"sections":[],"technologies":["car-t","in-vivo-car-t","parp-pet","neoantigen-mrna-vaccine","proton-therapy","proton-therapy-systems"],"targets":["brca","parp"],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":["robert-vonderheide","drew-weissman","angela-demichele","charu-aggarwal","robert-mach","leonard-abramson","jeffrey-bradley","alexander-perl","stephen-schuster","bruce-levine","carl-june","david-porter","susan-domchek"],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"Philadelphia","country":"US","lat":39.949,"lng":-75.194,"institutionType":"cancer-center","website":"https://www.pennmedicine.org/cancer","nci":"comprehensive","university":"University of Pennsylvania","programs":["CAR-T and in vivo CAR","mRNA","PARP PET","BRCA (Basser Center)"]},"route":"/institutions/penn-abramson/","neighbours":{"technology":[{"id":"car-t","kind":"technology","name":"CAR-T cell therapy","route":"/technologies/car-t/"},{"id":"glioma-car-t","kind":"technology","name":"CAR-T for glioma (IL13Rα2, GD2, EGFRvIII, multi-target)","route":"/technologies/glioma-car-t/"},{"id":"in-vivo-car-t","kind":"technology","name":"In vivo CAR-T","route":"/technologies/in-vivo-car-t/"},{"id":"parp-pet","kind":"technology","name":"PARP PET","route":"/technologies/parp-pet/"},{"id":"neoantigen-mrna-vaccine","kind":"technology","name":"Personalised neoantigen (mRNA) vaccines","route":"/technologies/neoantigen-mrna-vaccine/"},{"id":"proton-therapy","kind":"technology","name":"Proton therapy","route":"/technologies/proton-therapy/"},{"id":"proton-therapy-systems","kind":"technology","name":"Proton therapy machines: cyclotrons, synchrotrons and single-room systems","route":"/technologies/proton-therapy-systems/"}],"target":[{"id":"brca","kind":"target","name":"BRCA1 / BRCA2 (HRD)","route":"/targets/brca/"},{"id":"parp","kind":"target","name":"PARP","route":"/targets/parp/"}],"person":[{"id":"alexander-perl","kind":"person","name":"Alexander E. Perl","route":"/people/alexander-perl/"},{"id":"angela-demichele","kind":"person","name":"Angela DeMichele","route":"/people/angela-demichele/"},{"id":"bruce-levine","kind":"person","name":"Bruce L. Levine","route":"/people/bruce-levine/"},{"id":"carl-june","kind":"person","name":"Carl H. June","route":"/people/carl-june/"},{"id":"charu-aggarwal","kind":"person","name":"Charu Aggarwal","route":"/people/charu-aggarwal/"},{"id":"david-porter","kind":"person","name":"David L. Porter","route":"/people/david-porter/"},{"id":"drew-weissman","kind":"person","name":"Drew Weissman","route":"/people/drew-weissman/"},{"id":"emily-whitehead","kind":"person","name":"Emily Whitehead","route":"/people/emily-whitehead/"},{"id":"jeffrey-bradley","kind":"person","name":"Jeffrey D. Bradley","route":"/people/jeffrey-bradley/"},{"id":"leonard-abramson","kind":"person","name":"Leonard Abramson","route":"/people/leonard-abramson/"},{"id":"lynn-schuchter","kind":"person","name":"Lynn M. Schuchter","route":"/people/lynn-schuchter/"},{"id":"mitchell-schnall","kind":"person","name":"Mitchell D. Schnall","route":"/people/mitchell-schnall/"},{"id":"peter-odwyer","kind":"person","name":"Peter J. O'Dwyer","route":"/people/peter-odwyer/"},{"id":"robert-mach","kind":"person","name":"Robert H. Mach","route":"/people/robert-mach/"},{"id":"robert-vonderheide","kind":"person","name":"Robert H. Vonderheide","route":"/people/robert-vonderheide/"},{"id":"sean-parker","kind":"person","name":"Sean Parker","route":"/people/sean-parker/"},{"id":"stephan-grupp","kind":"person","name":"Stephan A. Grupp","route":"/people/stephan-grupp/"},{"id":"stephen-schuster","kind":"person","name":"Stephen J. Schuster","route":"/people/stephen-schuster/"},{"id":"susan-domchek","kind":"person","name":"Susan M. Domchek","route":"/people/susan-domchek/"}],"cancer":[{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"}],"paper":[{"id":"paper-bear-pancreatic-immunotherapy-review-cancer-cell-2020","kind":"paper","name":"Challenges and opportunities for pancreatic cancer immunotherapy","route":"/key-papers/paper-bear-pancreatic-immunotherapy-review-cancer-cell-2020/"},{"id":"paper-eliana-tisagenlecleucel-nejm-2018","kind":"paper","name":"ELIANA: the global trial that made tisagenlecleucel the first approved CAR-T therapy for children and young adults with relapsed ALL","route":"/key-papers/paper-eliana-tisagenlecleucel-nejm-2018/"},{"id":"paper-juliet-tisagenlecleucel-dlbcl-nejm-2019","kind":"paper","name":"JULIET: tisagenlecleucel for adults with relapsed or refractory diffuse large B-cell lymphoma","route":"/key-papers/paper-juliet-tisagenlecleucel-dlbcl-nejm-2019/"},{"id":"paper-maude-ctl019-all-nejm-2014","kind":"paper","name":"Maude 2014: CD19 CAR-T cells produce complete remission in 27 of 30 children and adults with relapsed ALL","route":"/key-papers/paper-maude-ctl019-all-nejm-2014/"},{"id":"paper-reiss-rucaparib-maintenance-brca-palb2-pancreatic-jco-2021","kind":"paper","name":"Phase II study of maintenance rucaparib in patients with platinum-sensitive advanced pancreatic cancer and a pathogenic germline or somatic variant in BRCA1, BRCA2, or PALB2","route":"/key-papers/paper-reiss-rucaparib-maintenance-brca-palb2-pancreatic-jco-2021/"},{"id":"paper-brca-risk-reducing-surgery-jama-2010","kind":"paper","name":"PROSE consortium: preventive surgery lowers cancer and death in BRCA1 and BRCA2 carriers","route":"/key-papers/paper-brca-risk-reducing-surgery-jama-2010/"},{"id":"paper-dbouk-caps5-stage-survival-jco-2022","kind":"paper","name":"The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival","route":"/key-papers/paper-dbouk-caps5-stage-survival-jco-2022/"}],"company":[{"id":"interius","kind":"company","name":"Interius BioTherapeutics","route":"/companies/interius/"}],"institution":[{"id":"chop","kind":"institution","name":"Children's Hospital of Philadelphia","route":"/institutions/chop/"},{"id":"nci","kind":"institution","name":"National Cancer Institute (NIH)","route":"/institutions/nci/"},{"id":"parker-institute","kind":"institution","name":"Parker Institute for Cancer Immunotherapy","route":"/institutions/parker-institute/"},{"id":"wistar","kind":"institution","name":"The Wistar Institute","route":"/institutions/wistar/"}],"idea":[{"id":"idea-moon-goals-conversation-trigger","kind":"idea","name":"Algorithm-triggered goals-of-care conversations before crisis","route":"/ideas/idea-moon-goals-conversation-trigger/"},{"id":"idea-fund-translational-institutes-gmp","kind":"idea","name":"Regional translational institutes with academic GMP suites and IND teams","route":"/ideas/idea-fund-translational-institutes-gmp/"}],"pathway":[{"id":"autophagy","kind":"pathway","name":"Autophagy","route":"/pathways/autophagy/"},{"id":"cancer-metabolism","kind":"pathway","name":"Cancer metabolism","route":"/pathways/cancer-metabolism/"},{"id":"circadian-control","kind":"pathway","name":"Circadian control","route":"/pathways/circadian-control/"},{"id":"microbiome-tumour","kind":"pathway","name":"Microbiome-tumour interactions","route":"/pathways/microbiome-tumour/"},{"id":"notch","kind":"pathway","name":"Notch signalling","route":"/pathways/notch/"}]}}