{"entity":{"id":"pdac-organoid-pharmacotyping","kind":"technology","name":"PDAC organoid pharmacotyping","aka":[],"tldr":"Growing a patient's pancreatic tumour as mini-organs in a dish and testing chemotherapies on them to pick the regimen most likely to work.","summary":"Tuveson (CSHL) and others established PDAC organoids with transcriptomic signatures predicting FOLFIRINOX versus gemcitabine sensitivity (Tiriac 2018). Prospective trials (e.g., PASS-01, HOPE) test organoid- or signature-guided first-line choice. Turnaround (~4-6 weeks) and take rate (~70%) are the practical limits; the GATA6 classical/basal-like signature is a faster proxy.","status":"emerging","asOf":"2026-09-06","links":[{"label":"Tiriac et al., Organoid profiling identifies common responders to chemotherapy in pancreatic cancer (Cancer Discovery 2018)","url":"https://doi.org/10.1158/2159-8290.CD-18-0349"}],"tags":[],"related":[],"cancers":["pancreatic"],"sections":["drug-discovery","diagnostics"],"technologies":["organoids","functional-drug-testing"],"targets":[],"drugs":[],"companies":[],"institutions":["cold-spring-harbor"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":["paper-tiriac-cancer-discov"],"journals":[],"dependsOn":[],"notes":[],"principle":"Endoscopic biopsy or resection tissue grown in Matrigel with defined factors; dose-response to drugs read by viability assays.","strengths":["Direct functional read-out where genomics offers little","Platform for RAS-inhibitor combination testing"],"limitations":["Timeline exceeds the clinical decision window for many patients","No stroma or immune compartment"]},"route":"/technologies/pdac-organoid-pharmacotyping/","neighbours":{"cancer":[{"id":"borderline-resectable-pdac","kind":"cancer","name":"Borderline resectable pancreatic ductal adenocarcinoma","route":"/cancers/borderline-resectable-pdac/"},{"id":"pancreatic-acinar-cell-carcinoma","kind":"cancer","name":"Pancreatic acinar cell carcinoma","route":"/cancers/pancreatic-acinar-cell-carcinoma/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}],"section":[{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"},{"id":"drug-discovery","kind":"section","name":"Drug Discovery Platforms","route":"/fronts/drug-discovery/"}],"technology":[{"id":"functional-precision-medicine-haematology","kind":"technology","name":"Ex vivo drug sensitivity screening in blood cancers (EXALT)","route":"/technologies/functional-precision-medicine-haematology/"},{"id":"functional-drug-testing","kind":"technology","name":"Functional (ex vivo) drug testing","route":"/technologies/functional-drug-testing/"},{"id":"organoid-guided-therapy-scale","kind":"technology","name":"Organoid-guided therapy at scale","route":"/technologies/organoid-guided-therapy-scale/"},{"id":"organoids","kind":"technology","name":"Patient-derived organoids","route":"/technologies/organoids/"}],"institution":[{"id":"cold-spring-harbor","kind":"institution","name":"Cold Spring Harbor Laboratory","route":"/institutions/cold-spring-harbor/"}],"paper":[{"id":"paper-tiriac-cancer-discov","kind":"paper","name":"Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer","route":"/key-papers/paper-tiriac-cancer-discov/"}],"term":[{"id":"classical-vs-basal-like","kind":"term","name":"Classical versus basal-like (squamous) subtypes of pancreatic cancer, and GATA6","route":"/terms/classical-vs-basal-like/"}],"person":[{"id":"david-tuveson","kind":"person","name":"David A. Tuveson","route":"/people/david-tuveson/"}],"bottleneck":[{"id":"b-preclinical-models","kind":"bottleneck","name":"Lab models that fail to predict what happens in patients","route":"/bottlenecks/b-preclinical-models/"}],"idea":[{"id":"idea-tr2-organoid-coclinical-arms","kind":"idea","name":"Grow each trial patient's tumour as organoids to decide which platform arm opens next","route":"/ideas/idea-tr2-organoid-coclinical-arms/"}],"roadmap":[{"id":"drug-discovery-roadmap","kind":"roadmap","name":"Drug discovery roadmap: screening in mice → maps of dependency → designing in silico","route":"/roadmaps/drug-discovery-roadmap/"}]}}