{"entity":{"id":"paul-nurse","kind":"person","name":"Paul Nurse","aka":[],"tldr":"Nobel laureate who discovered how cyclin-dependent kinases control cell division, and founding director of the Crick.","summary":"Paul Nurse is Director of The Francis Crick Institute in London and a Nobel laureate. His specialisms are the cell cycle, cyclin-dependent kinases and institute leadership. He shared the 2001 Nobel Prize for discovering key regulators of the cell cycle, the biology behind the CDK4/6 inhibitors now used in cancer treatment. His Nature paper on the genetic control of cell size at cell division in yeast was part of that foundational work. He has led the Francis Crick Institute since its foundation, and his Crick profile is linked.","asOf":"2026-09-08","links":[{"label":"Crick","url":"https://www.crick.ac.uk/"}],"tags":[],"related":[],"cancers":[],"sections":[],"technologies":[],"targets":["cdk4-6"],"drugs":[],"companies":[],"institutions":["francis-crick"],"pathways":["p53-cell-cycle"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Director, Francis Crick Institute; Nobel laureate","institutionId":"francis-crick","specialisms":["Cell cycle","Cyclin-dependent kinases","Institute leadership"],"profiles":[{"label":"Crick","url":"https://www.crick.ac.uk/"}],"papers":[{"title":"Genetic control of cell size at cell division in yeast","journal":"Nature","year":1975,"doi":"10.1038/256547a0"}],"orcid":"0000-0002-9244-7787"},"route":"/people/paul-nurse/","neighbours":{"target":[{"id":"cdk4-6","kind":"target","name":"CDK4/6","route":"/targets/cdk4-6/"}],"institution":[{"id":"francis-crick","kind":"institution","name":"The Francis Crick Institute","route":"/institutions/francis-crick/"},{"id":"wellcome","kind":"institution","name":"Wellcome","route":"/institutions/wellcome/"}],"pathway":[{"id":"p53-cell-cycle","kind":"pathway","name":"p53 / RB / cell-cycle checkpoint","route":"/pathways/p53-cell-cycle/"}]}}