{"entity":{"id":"paul-brown","kind":"person","name":"Paul D. Brown","aka":[],"tldr":"Mayo Clinic radiation oncologist whose trials showed that focused radiosurgery preserves thinking and memory better than whole-brain radiotherapy for brain metastases, and that sparing the hippocampus reduces cognitive harm when whole-brain treatment is needed.","summary":"Paul Brown is a radiation oncologist at Mayo Clinic in Rochester who leads the North American cooperative-group trials on brain metastases. He was first author of the 2016 JAMA report of Alliance N0574, which showed less cognitive decline with radiosurgery alone than with radiosurgery plus whole-brain radiotherapy for one to three brain metastases; of the 2017 Lancet Oncology report of N107C, which established postoperative radiosurgery to the surgical cavity; and of the 2020 Journal of Clinical Oncology report of NRG CC001, which showed hippocampal avoidance with memantine reduces cognitive toxicity of whole-brain radiotherapy.","asOf":"2026-09-18","links":[],"tags":["brain","radiotherapy","trialist"],"related":[],"cancers":["secondary-brain-tumours","brain-tumours"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["mayo-clinic"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":["paper-alliance-n0574-brown-jama-2016","paper-n107c-brown-lancet-oncol-2017","paper-nrg-cc001-brown-jco-2020"],"journals":[],"dependsOn":[],"notes":[],"role":"Radiation oncologist, Mayo Clinic","institutionId":"mayo-clinic","specialisms":["Brain metastases","Stereotactic radiosurgery","Cognitive outcomes of radiotherapy"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Brown%5BAuthor%5D"}],"papers":[{"title":"Alliance N0574: radiosurgery alone versus radiosurgery plus whole-brain radiotherapy for one to three brain metastases","journal":"JAMA","year":2016,"url":"https://doi.org/10.1001/jama.2016.9839","doi":"10.1001/jama.2016.9839"},{"title":"N107C/CEC.3: postoperative radiosurgery versus whole-brain radiotherapy after resection of a brain metastasis","journal":"The Lancet Oncology","year":2017,"url":"https://doi.org/10.1016/S1470-2045(17)30441-2","doi":"10.1016/S1470-2045(17)30441-2"},{"title":"NRG CC001: hippocampal-avoidance whole-brain radiotherapy plus memantine for brain metastases","journal":"Journal of Clinical Oncology","year":2020,"url":"https://doi.org/10.1200/JCO.19.02767","doi":"10.1200/JCO.19.02767"}]},"route":"/people/paul-brown/","neighbours":{"cancer":[{"id":"brain-tumours","kind":"cancer","name":"Brain and spinal cord tumours (all types)","route":"/cancers/brain-tumours/"},{"id":"secondary-brain-tumours","kind":"cancer","name":"Brain metastases (secondary brain tumours)","route":"/cancers/secondary-brain-tumours/"}],"institution":[{"id":"mayo-clinic","kind":"institution","name":"Mayo Clinic","route":"/institutions/mayo-clinic/"}],"paper":[{"id":"paper-alliance-n0574-brown-jama-2016","kind":"paper","name":"Alliance N0574: radiosurgery alone versus radiosurgery plus whole-brain radiotherapy for one to three brain metastases","route":"/key-papers/paper-alliance-n0574-brown-jama-2016/"},{"id":"paper-n107c-brown-lancet-oncol-2017","kind":"paper","name":"N107C/CEC.3: postoperative radiosurgery versus whole-brain radiotherapy after resection of a brain metastasis","route":"/key-papers/paper-n107c-brown-lancet-oncol-2017/"},{"id":"paper-nrg-cc001-brown-jco-2020","kind":"paper","name":"NRG CC001: hippocampal-avoidance whole-brain radiotherapy plus memantine for brain metastases","route":"/key-papers/paper-nrg-cc001-brown-jco-2020/"}]}}