{"entity":{"id":"patrick-wen","kind":"person","name":"Patrick Y. Wen","aka":[],"tldr":"Neuro-oncologist who created the RANO response criteria used in every brain tumour trial and leads glioblastoma drug development.","summary":"Patrick Wen led the Response Assessment in Neuro-Oncology (RANO) working group that replaced the Macdonald criteria and standardised how glioma trials measure response, and has been principal investigator of numerous targeted therapy trials in glioblastoma including the INDIGO steering committee. He directs neuro-oncology at Dana-Farber, edits Neuro-Oncology, and co-chairs the Society for Neuro-Oncology's trial initiatives.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Wen%20PY%5BAuthor%5D%20glioblastoma%20RANO"}],"tags":["glioma","response-criteria","neuro-oncology"],"related":[],"cancers":["glioblastoma"],"sections":[],"technologies":["mri"],"targets":[],"drugs":["vorasidenib"],"companies":[],"institutions":["dana-farber"],"pathways":[],"terms":[],"trials":["indigo"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["neuro-oncology"],"dependsOn":[],"notes":[],"role":"Director, Center for Neuro-Oncology, Dana-Farber Cancer Institute; Professor of Neurology, Harvard Medical School","institutionId":"dana-farber","specialisms":["Neuro-oncology","Glioblastoma","Response assessment","Targeted therapy trials"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Wen%20PY%5BAuthor%5D%20glioblastoma%20RANO"}],"papers":[{"title":"Updated response assessment criteria for high-grade gliomas: Response Assessment in Neuro-Oncology working group (RANO)","journal":"JCO","year":2010,"doi":"10.1200/JCO.2009.26.3541"},{"title":"Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions","journal":"Neuro-Oncology","year":2020,"doi":"10.1093/neuonc/noaa106"}]},"route":"/people/patrick-wen/","neighbours":{"cancer":[{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"}],"technology":[{"id":"mri","kind":"technology","name":"MRI","route":"/technologies/mri/"}],"drug":[{"id":"vorasidenib","kind":"drug","name":"Vorasidenib","route":"/drugs/vorasidenib/"}],"institution":[{"id":"dana-farber","kind":"institution","name":"Dana-Farber Brigham Cancer Center","route":"/institutions/dana-farber/"}],"trial":[{"id":"indigo","kind":"trial","name":"INDIGO","route":"/trials/indigo/"}],"journal":[{"id":"neuro-oncology","kind":"journal","name":"Neuro-Oncology","route":"/journals/neuro-oncology/"}]}}