{"entity":{"id":"patrick-mehlen","kind":"person","name":"Patrick Mehlen","aka":[],"tldr":"Cancer biologist who discovered the dependence-receptor concept and took netrin-1 blockade from bench to clinical trials at Centre Léon Bérard.","summary":"Patrick Mehlen directs fundamental and translational research at Centre Léon Bérard and leads the Cancer Research Center of Lyon (CRCL). His laboratory established the concept of dependence receptors and showed that blocking netrin-1 can inhibit tumour growth, work that led to the anti-netrin-1 antibody now in clinical trials and reported in Nature in 2023.","asOf":"2026-09-10","links":[{"label":"Institution profile","url":"https://www.centreleonberard.fr/comment-est-organise-le-centre-leon-berard"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Mehlen+P%5BAuthor%5D"}],"tags":["leadership","clinician-scientist","cancer biology","drug development"],"related":[],"cancers":["endometrial"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["centre-leon-berard"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Director of Fundamental and Translational Research and of the Cancer Research Center of Lyon (CRCL)","institutionId":"centre-leon-berard","specialisms":["Cancer cell biology","Dependence receptors","Netrin-1","Translational research"],"profiles":[{"label":"Institution profile","url":"https://www.centreleonberard.fr/comment-est-organise-le-centre-leon-berard"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Mehlen+P%5BAuthor%5D"}],"papers":[{"title":"Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer","journal":"Nature","year":2023,"url":"https://doi.org/10.1038/s41586-023-06367-z","doi":"10.1038/s41586-023-06367-z"}],"orcid":"0000-0003-1743-5417"},"route":"/people/patrick-mehlen/","neighbours":{"cancer":[{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"}],"institution":[{"id":"centre-leon-berard","kind":"institution","name":"Centre Léon Bérard","route":"/institutions/centre-leon-berard/"}]}}