{"entity":{"id":"paper-wotherspoon-h-pylori-malt-lancet-1993","kind":"paper","name":"Regression of primary low-grade gastric MALT lymphoma after eradication of Helicobacter pylori","aka":[],"tldr":"In six patients, eradicating the stomach bacterium Helicobacter pylori with antibiotics made low-grade gastric lymphoma regress, proving that a cancer could be caused by, and treated through, a chronic infection.","summary":"Case series of six patients with primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type and Helicobacter pylori infection treated with antibiotics to eradicate the organism.\n\nIn five patients the lymphoma regressed histologically and endoscopically after eradication, supporting the hypothesis that the lymphoma is driven by antigenic stimulation from the infection.","asOf":"2026-09-17","links":[{"label":"Lancet 1993","url":"https://doi.org/10.1016/0140-6736(93)91409-F"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/8102719/"}],"tags":[],"related":["lymphoma-roadmap","paper-ielsg-19-chlorambucil-rituximab-malt-jco-2017"],"cancers":["marginal-zone-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["lancet"],"dependsOn":[],"notes":[],"journal":"The Lancet","year":1993,"doi":"10.1016/0140-6736(93)91409-F","pmid":"8102719","authors":"Wotherspoon AC, Doglioni C, Diss TC, et al.","paperType":"observational","findings":["Lymphoma regression in five of six patients after Helicobacter pylori eradication."],"whatItMeans":"Antibiotic eradication is the first-line treatment for Helicobacter pylori-positive gastric MALT lymphoma, curing most patients without chemotherapy or radiotherapy.","caveats":["Six patients; lymphomas with t(11;18) or deep invasion often do not respond and need radiotherapy."],"changedPractice":true,"participants":6},"route":"/key-papers/paper-wotherspoon-h-pylori-malt-lancet-1993/","neighbours":{"roadmap":[{"id":"lymphoma-roadmap","kind":"roadmap","name":"Lymphoma roadmap: from a jaw tumour in Uganda and the first human cancer virus to gene-expression subtypes, PET-adapted chemotherapy, CAR-T cells, bispecific antibodies and the genetics-directed trials now recruiting","route":"/roadmaps/lymphoma-roadmap/"}],"paper":[{"id":"paper-ielsg-19-chlorambucil-rituximab-malt-jco-2017","kind":"paper","name":"Final results of the IELSG-19 randomized trial of mucosa-associated lymphoid tissue lymphoma: improved event-free and progression-free survival with rituximab plus chlorambucil versus either chlorambucil or rituximab monotherapy","route":"/key-papers/paper-ielsg-19-chlorambucil-rituximab-malt-jco-2017/"}],"cancer":[{"id":"malt-lymphoma","kind":"cancer","name":"Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)","route":"/cancers/malt-lymphoma/"},{"id":"gastric-malt-lymphoma","kind":"cancer","name":"Gastric MALT lymphoma","route":"/cancers/gastric-malt-lymphoma/"},{"id":"marginal-zone-lymphoma","kind":"cancer","name":"Marginal zone lymphoma","route":"/cancers/marginal-zone-lymphoma/"}],"journal":[{"id":"lancet","kind":"journal","name":"The Lancet","route":"/journals/lancet/"}],"term":[{"id":"lymphoma-tx-h-pylori-eradication","kind":"term","name":"Helicobacter pylori eradication as cancer treatment in gastric MALT lymphoma","route":"/terms/lymphoma-tx-h-pylori-eradication/"}]}}