{"entity":{"id":"owen-sansom","kind":"person","name":"Owen Sansom","aka":[],"tldr":"Glasgow cancer biologist who directs the CRUK Scotland Institute and is Scientific Director of the CRUK Scotland Centre, known for mouse models of colorectal and pancreatic cancer.","summary":"Prof. Owen Sansom is Scientific Director of the CRUK Scotland Centre and Director of the Cancer Research UK Scotland Institute (formerly the Beatson Institute) in Glasgow. His laboratory uses genetically engineered mouse models to dissect Wnt/APC signalling and tumour initiation in the intestine and pancreas, informing prevention and therapy strategies. He is a Fellow of the Royal Society of Edinburgh.","asOf":"2026-09-10","links":[{"label":"Institution profile","url":"https://www.crukscotlandcentre.ac.uk/about-us/"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Sansom+OJ%5BAuthor%5D"}],"tags":["leadership","clinician-scientist","colorectal cancer","pancreatic cancer"],"related":[],"cancers":["colorectal","pancreatic"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["beatson-glasgow"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Scientific Director, CRUK Scotland Centre","institutionId":"beatson-glasgow","specialisms":["Colorectal cancer biology","Pancreatic cancer","Wnt signalling"],"profiles":[{"label":"Institution profile","url":"https://www.crukscotlandcentre.ac.uk/about-us/"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Sansom+OJ%5BAuthor%5D"}],"papers":[{"title":"Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis","journal":"Cancer Cell","year":2019,"doi":"10.1016/j.ccell.2019.08.003"},{"title":"Reserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract","journal":"Science Signaling","year":2015,"doi":"10.1126/scisignal.aaa7540"},{"title":"mTORC1-mediated translational elongation limits intestinal tumour initiation and growth","journal":"Nature","year":2014,"doi":"10.1038/nature13896"}],"orcid":"0000-0001-9540-3010"},"route":"/people/owen-sansom/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}],"institution":[{"id":"beatson-glasgow","kind":"institution","name":"Beatson West of Scotland Cancer Centre / CRUK Scotland Institute","route":"/institutions/beatson-glasgow/"},{"id":"cruk","kind":"institution","name":"Cancer Research UK","route":"/institutions/cruk/"}],"paper":[{"id":"paper-bailey-molecular-subtypes-pancreatic-nature-2016","kind":"paper","name":"Genomic analyses identify molecular subtypes of pancreatic cancer","route":"/key-papers/paper-bailey-molecular-subtypes-pancreatic-nature-2016/"}]}}