{"entity":{"id":"ovarian-function-suppression","kind":"term","name":"Ovarian function suppression (OFS)","aka":[],"tldr":"Temporarily switching off the ovaries with injections (or removing them) so a premenopausal woman's cancer is starved of oestrogen.","summary":"GnRH agonists (goserelin, leuprolide), oophorectomy, or ovarian irradiation. SOFT/TEXT established OFS + aromatase inhibitor for higher-risk premenopausal women; absolute benefit is largest in those under 35 or needing chemotherapy. Required for aromatase inhibitors in premenopausal women, and the likely explanation for chemotherapy's benefit in premenopausal RxPONDER patients.","asOf":"2026-09-07","links":[{"label":"NCI Dictionary of Cancer Terms: ovarian suppression","url":"https://www.cancer.gov/publications/dictionaries/cancer-terms/def/ovarian-suppression"}],"tags":[],"related":[],"cancers":["breast-hr-positive"],"sections":[],"technologies":[],"targets":[],"drugs":["goserelin","exemestane","tamoxifen"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["soft-text","rxponder"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Clinical","wikipediaChecked":"2026-09-22"},"route":"/terms/ovarian-function-suppression/","neighbours":{"cancer":[{"id":"breast-hr-positive","kind":"cancer","name":"HR-positive / HER2-negative breast cancer","route":"/cancers/breast-hr-positive/"}],"drug":[{"id":"exemestane","kind":"drug","name":"Exemestane","route":"/drugs/exemestane/"},{"id":"goserelin","kind":"drug","name":"Goserelin / leuprolide (ovarian function suppression)","route":"/drugs/goserelin/"},{"id":"leuprolide","kind":"drug","name":"Leuprolide (leuprorelin) and GnRH agonists","route":"/drugs/leuprolide/"},{"id":"tamoxifen","kind":"drug","name":"Tamoxifen","route":"/drugs/tamoxifen/"}],"trial":[{"id":"rxponder","kind":"trial","name":"RxPONDER (SWOG S1007)","route":"/trials/rxponder/"},{"id":"soft-text","kind":"trial","name":"SOFT & TEXT","route":"/trials/soft-text/"}],"technology":[{"id":"cancer-treatment-bone-loss","kind":"technology","name":"Bone loss caused by cancer treatment, and what rebuilds it","route":"/technologies/cancer-treatment-bone-loss/"},{"id":"menopause-after-cancer-treatment","kind":"technology","name":"Menopause brought on by cancer treatment, and the options for it","route":"/technologies/menopause-after-cancer-treatment/"},{"id":"fertility-preservation","kind":"technology","name":"Oncofertility and fertility preservation","route":"/technologies/fertility-preservation/"},{"id":"ovarian-function-after-chemotherapy","kind":"technology","name":"Ovarian function after chemotherapy: who recovers, and when","route":"/technologies/ovarian-function-after-chemotherapy/"}]}}