{"entity":{"id":"orchiectomy","kind":"term","name":"Orchiectomy","aka":["orchidectomy","radical inguinal orchiectomy","surgical castration","bilateral orchiectomy"],"tldr":"Surgical removal of a testicle: the diagnostic and first curative step for testicular cancer, or of both, as a cheap permanent form of hormone therapy in prostate cancer.","summary":"Radical inguinal orchiectomy (through the groin, not the scrotum, to avoid seeding) removes the tumour and gives the histology (seminoma vs non-seminoma) that guides surveillance, carboplatin or BEP chemotherapy. Bilateral orchiectomy lowers testosterone to castrate levels within hours and remains the most cost-effective androgen deprivation worldwide, though most men choose GnRH drugs for reversibility. Testosterone falls to castrate levels permanently, so the hot flushes, bone loss and fatigue of androgen deprivation follow.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Orchiectomy","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Orchiectomy"}],"tags":[],"related":["adt","castration-resistance"],"cancers":["prostate"],"sections":["surgery","hormonal"],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Procedures"},"route":"/terms/orchiectomy/","neighbours":{"term":[{"id":"adt","kind":"term","name":"Androgen deprivation therapy (ADT)","route":"/terms/adt/"},{"id":"castration-resistance","kind":"term","name":"Castration-resistant prostate cancer (CRPC)","route":"/terms/castration-resistance/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"section":[{"id":"hormonal","kind":"section","name":"Hormonal Therapy","route":"/fronts/hormonal/"},{"id":"surgery","kind":"section","name":"Surgery & Interventional","route":"/fronts/surgery/"}]}}