{"entity":{"id":"oral-serd","kind":"term","name":"Oral SERD","aka":[],"tldr":"An oral SERD is a pill that destroys the oestrogen receptor rather than just blocking it, replacing the monthly fulvestrant injection.","summary":"Selective oestrogen receptor degraders taken orally: elacestrant (2023), imlunestrant (2025), camizestrant (2026), giredestrant (filed), with palazestrant and others behind. Benefit as monotherapy is confined to ESR1-mutant disease; combination with CDK4/6 or everolimus extends benefit to wild-type tumours (EMBER-3, evERA). Upfront replacement of aromatase inhibitors in unselected first-line disease failed in persevERA. Adjuvant results (lidERA) are positive.","asOf":"2026-09-07","wikipedia":"https://en.wikipedia.org/wiki/Selective_estrogen_receptor_degrader","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Selective_estrogen_receptor_degrader"}],"tags":[],"related":[],"cancers":["breast-hr-positive"],"sections":[],"technologies":[],"targets":["estrogen-receptor"],"drugs":["elacestrant","imlunestrant","camizestrant","giredestrant","fulvestrant"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Treatment jargon"},"route":"/terms/oral-serd/","neighbours":{"cancer":[{"id":"breast-hr-positive","kind":"cancer","name":"HR-positive / HER2-negative breast cancer","route":"/cancers/breast-hr-positive/"}],"target":[{"id":"estrogen-receptor","kind":"target","name":"Estrogen receptor (ERα)","route":"/targets/estrogen-receptor/"}],"drug":[{"id":"camizestrant","kind":"drug","name":"Camizestrant","route":"/drugs/camizestrant/"},{"id":"elacestrant","kind":"drug","name":"Elacestrant","route":"/drugs/elacestrant/"},{"id":"fulvestrant","kind":"drug","name":"Fulvestrant","route":"/drugs/fulvestrant/"},{"id":"giredestrant","kind":"drug","name":"Giredestrant","route":"/drugs/giredestrant/"},{"id":"imlunestrant","kind":"drug","name":"Imlunestrant","route":"/drugs/imlunestrant/"}],"trial":[{"id":"ember-3","kind":"trial","name":"EMBER-3","route":"/trials/ember-3/"}]}}