{"entity":{"id":"oncotype-dx-gps","kind":"drug","name":"Oncotype DX Genomic Prostate Score","aka":[],"tldr":"A 17-gene biopsy test that helps men with newly diagnosed low-risk prostate cancer decide whether to watch or treat.","summary":"Developed by Genomic Health and sold by Exact Sciences until MDxHealth acquired the test in 2022, the Genomic Prostate Score predicts adverse pathology at prostatectomy and long-term metastasis and death, validated in surgical cohorts and in the Kaiser Permanente and Veterans Affairs populations. NCCN lists it for very-low to favourable-intermediate risk disease. In practice it is ordered when a man and his urologist are on the fence about active surveillance. As with Prolaris and Decipher, evidence that the test changes long-term outcomes rather than decisions is lacking.","status":"established","asOf":"2026-09-10","links":[{"label":"MDxHealth: Oncotype DX GPS (page moved; nearest live section)","url":"https://mdxhealth.com/"}],"tags":["test"],"related":["decipher-prostate","prolaris"],"cancers":["prostate"],"sections":[],"technologies":["rna-seq","active-surveillance"],"targets":[],"drugs":[],"companies":["mdxhealth"],"institutions":[],"pathways":[],"terms":["gleason-grade-group","active-surveillance-term"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["What a result means: a low GPS supports active surveillance; higher scores predict more aggressive disease at surgery."],"brand":"Oncotype DX GPS","modality":"Gene-expression prognostic assay (17-gene Genomic Prostate Score)","mechanism":"RT-PCR of 12 cancer genes across four pathways (androgen signalling, proliferation, cellular organisation, stromal response) and five reference genes on biopsy tissue, giving a 0-100 Genomic Prostate Score.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/oncotype-dx-gps/","neighbours":{"drug":[{"id":"decipher-prostate","kind":"drug","name":"Decipher Prostate","route":"/drugs/decipher-prostate/"},{"id":"prolaris","kind":"drug","name":"Prolaris","route":"/drugs/prolaris/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"technology":[{"id":"active-surveillance","kind":"technology","name":"Active surveillance","route":"/technologies/active-surveillance/"},{"id":"rna-seq","kind":"technology","name":"RNA sequencing & expression profiling","route":"/technologies/rna-seq/"}],"company":[{"id":"mdxhealth","kind":"company","name":"MDxHealth","route":"/companies/mdxhealth/"}],"term":[{"id":"active-surveillance-term","kind":"term","name":"Active surveillance and observation","route":"/terms/active-surveillance-term/"},{"id":"gleason-grade-group","kind":"term","name":"Gleason score / Grade Group","route":"/terms/gleason-grade-group/"}]}}