{"entity":{"id":"oncology-real-world-data","kind":"technology","name":"Oncology EHR and real-world data platforms","aka":[],"tldr":"Databases built from millions of real patient records, used to see how treatments work outside trials and to run studies without new trials.","summary":"Flatiron Health (Roche; oncology EHR OncoEMR plus the Flatiron-Foundation clinico-genomic database), Tempus (multimodal clinical-molecular data), ConcertAI, COTA, Syapse, TriNetX, Komodo Health, Optum, and Datavant (tokenised linkage) assemble and curate real-world oncology data. Used for external control arms, label expansions (FDA's RWE framework), health-economic models, and biomarker discovery; standardisation via OMOP/OHDSI and mCODE (HL7 FHIR) is the interoperability layer.","status":"established","asOf":"2026-09-08","links":[{"label":"FDA: Real-World Evidence programme","url":"https://www.fda.gov/science-research/science-and-research-special-topics/real-world-evidence"}],"tags":["supporting"],"related":[],"cancers":[],"sections":["ai-computation","diagnostics"],"technologies":["ai-trial-matching","cgp"],"targets":[],"drugs":[],"companies":["flatiron-health","tempus","concertai","cota-healthcare","trinetx","komodo-health","datavant"],"institutions":[],"pathways":[],"terms":["real-world-evidence","omop-ohdsi","mcode"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"principle":"Structured and abstracted EHR data, claims, genomics, and mortality linked with privacy-preserving tokens; curated to common data models and analysed with target-trial emulation methods.","strengths":["Scale and speed","Populations trials exclude (older, sicker, rarer)"],"limitations":["Confounding and missing data","Inconsistent endpoints (real-world progression)","Access and cost"]},"route":"/technologies/oncology-real-world-data/","neighbours":{"section":[{"id":"ai-computation","kind":"section","name":"AI & Computation","route":"/fronts/ai-computation/"},{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"}],"technology":[{"id":"ai-trial-matching","kind":"technology","name":"AI trial matching & clinical decision support","route":"/technologies/ai-trial-matching/"},{"id":"cancer-registries-surveillance","kind":"technology","name":"Cancer registries and population surveillance","route":"/technologies/cancer-registries-surveillance/"},{"id":"community-oncology-networks","kind":"technology","name":"Community oncology and site networks","route":"/technologies/community-oncology-networks/"},{"id":"cgp","kind":"technology","name":"Comprehensive genomic profiling","route":"/technologies/cgp/"},{"id":"federated-learning-medical-ai","kind":"technology","name":"Federated learning and privacy-preserving AI","route":"/technologies/federated-learning-medical-ai/"},{"id":"genomics-cloud-platforms","kind":"technology","name":"Genomics cloud and secure research environments","route":"/technologies/genomics-cloud-platforms/"},{"id":"hospital-information-systems-oncology","kind":"technology","name":"Oncology EHR modules and treatment pathways","route":"/technologies/hospital-information-systems-oncology/"}],"company":[{"id":"concertai","kind":"company","name":"ConcertAI","route":"/companies/concertai/"},{"id":"cota-healthcare","kind":"company","name":"COTA","route":"/companies/cota-healthcare/"},{"id":"datavant","kind":"company","name":"Datavant","route":"/companies/datavant/"},{"id":"epic-systems","kind":"company","name":"Epic Systems","route":"/companies/epic-systems/"},{"id":"flatiron-health","kind":"company","name":"Flatiron Health (Roche)","route":"/companies/flatiron-health/"},{"id":"iqvia","kind":"company","name":"IQVIA","route":"/companies/iqvia/"},{"id":"komodo-health","kind":"company","name":"Komodo Health","route":"/companies/komodo-health/"},{"id":"mckesson-us-oncology","kind":"company","name":"McKesson / The US Oncology Network","route":"/companies/mckesson-us-oncology/"},{"id":"tempus","kind":"company","name":"Tempus AI","route":"/companies/tempus/"},{"id":"trinetx","kind":"company","name":"TriNetX","route":"/companies/trinetx/"}],"term":[{"id":"21st-century-cures-act","kind":"term","name":"21st Century Cures Act","route":"/terms/21st-century-cures-act/"},{"id":"european-health-data-space","kind":"term","name":"European Health Data Space Regulation (EU) 2025/327","route":"/terms/european-health-data-space/"},{"id":"external-control-arm","kind":"term","name":"External and synthetic control arms","route":"/terms/external-control-arm/"},{"id":"gdpr","kind":"term","name":"GDPR and health data (Regulation (EU) 2016/679)","route":"/terms/gdpr/"},{"id":"hipaa","kind":"term","name":"HIPAA (Health Insurance Portability and Accountability Act)","route":"/terms/hipaa/"},{"id":"mcode","kind":"term","name":"mCODE (minimal Common Oncology Data Elements)","route":"/terms/mcode/"},{"id":"omop-ohdsi","kind":"term","name":"OMOP common data model and OHDSI","route":"/terms/omop-ohdsi/"},{"id":"real-world-evidence","kind":"term","name":"Real-world evidence","route":"/terms/real-world-evidence/"},{"id":"registry-based-trial","kind":"term","name":"Registry-based randomised trial","route":"/terms/registry-based-trial/"},{"id":"uk-data-protection-act","kind":"term","name":"UK Data Protection Act 2018 and health data law","route":"/terms/uk-data-protection-act/"}]}}