{"entity":{"id":"olivier-chinot","kind":"person","name":"Olivier L. Chinot","aka":[],"tldr":"Marseille neuro-oncologist who was lead author of AVAglio, the trial that showed adding bevacizumab to standard glioblastoma treatment delays progression but does not lengthen life.","summary":"Olivier Chinot leads neuro-oncology at Hôpital de la Timone in Marseille. He was first author of the 2014 New England Journal of Medicine report of AVAglio, the phase 3 trial in which bevacizumab added to radiotherapy and temozolomide improved progression-free survival but not overall survival in newly diagnosed glioblastoma, a result echoed by the parallel RTOG 0825 trial and which limited the drug's role in the disease.","asOf":"2026-09-18","links":[],"tags":["brain","trialist"],"related":[],"cancers":["glioblastoma","brain-tumours"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["ap-hm-timone"],"pathways":[],"terms":[],"trials":["avaglio"],"people":[],"bottlenecks":[],"keyPapers":["paper-olivier-chinot-n-engl-j-med-2014","paper-olivier-chinot-nat-rev-clin-oncol-2021","paper-olivier-chinot-cancer-treat-rev-2020"],"journals":[],"dependsOn":[],"notes":[],"role":"Neuro-oncologist, Aix-Marseille University and Hôpital de la Timone","institutionId":"ap-hm-timone","specialisms":["Glioblastoma","Anti-angiogenic therapy","Neuro-oncology trials"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Chinot%5BAuthor%5D"}],"papers":[{"title":"Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma","journal":"New England Journal of Medicine","year":2014,"url":"https://doi.org/10.1056/nejmoa1308345","doi":"10.1056/nejmoa1308345","note":"Europe PMC author record matched by affiliation (Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille); 1936 citations on Europe PMC."},{"title":"EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood","journal":"Nature Reviews Clinical Oncology","year":2021,"url":"https://doi.org/10.1038/s41571-020-00447-z","doi":"10.1038/s41571-020-00447-z","note":"Europe PMC author record matched by affiliation (Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille); 1583 citations on Europe PMC."},{"title":"Bevacizumab (Avastin®) in cancer treatment: A review of 15 years of clinical experience and future outlook","journal":"Cancer treatment reviews","year":2020,"url":"https://doi.org/10.1016/j.ctrv.2020.102017","doi":"10.1016/j.ctrv.2020.102017","note":"Europe PMC author record matched by affiliation (Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille); 933 citations on Europe PMC."}],"orcid":"0000-0001-6317-9691"},"route":"/people/olivier-chinot/","neighbours":{"cancer":[{"id":"brain-tumours","kind":"cancer","name":"Brain and spinal cord tumours (all types)","route":"/cancers/brain-tumours/"},{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"}],"institution":[{"id":"ap-hm-timone","kind":"institution","name":"Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille","route":"/institutions/ap-hm-timone/"}],"trial":[{"id":"avaglio","kind":"trial","name":"AVAglio","route":"/trials/avaglio/"}],"paper":[{"id":"paper-olivier-chinot-cancer-treat-rev-2020","kind":"paper","name":"Bevacizumab (Avastin®) in cancer treatment: A review of 15 years of clinical experience and future outlook","route":"/key-papers/paper-olivier-chinot-cancer-treat-rev-2020/"},{"id":"paper-olivier-chinot-n-engl-j-med-2014","kind":"paper","name":"Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma","route":"/key-papers/paper-olivier-chinot-n-engl-j-med-2014/"},{"id":"paper-olivier-chinot-nat-rev-clin-oncol-2021","kind":"paper","name":"EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood","route":"/key-papers/paper-olivier-chinot-nat-rev-clin-oncol-2021/"}]}}